MULTIFUNCTIONAL MOLECULAR RECOGNITION OF ATP, ADP AND AMP NUCLEOTIDES BY THE NOVEL RECEPTOR 2,6,10,13,17,21-HEXAAZA[22]METACYCLOPHANE
MULTIFUNCTIONAL MOLECULAR RECOGNITION OF ATP, ADP AND AMP NUCLEOTIDES BY THE NOVEL RECEPTOR 2,6,10,13,17,21-HEXAAZA[22]METACYCLOPHANE
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DOI：
10.1039/c39950002237
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发表时间：
1995-11-07
影响因子：
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通讯作者：
SORIANO, C
中科院分区：
文献类型：
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作者：
AGUILAR, JA;GARCIAESPANA, E;SORIANO, C
新型环蕃受体2，6，10，13，17，21-六氮杂[22]间环蕃L呈现出一种分子结构，能够通过静电、氢键和π堆积相互作用在水溶液中识别ATP、ADP和AMP;静电相互作用发生在L的聚铵位点和核苷的磷酸链之间，并且π-堆积相互作用发生在作为大环骨架的非侧基组成部分结合到受体中的间亚苯基亚基和核苷酸的腺嘌呤环之间。
The novel cyclophane receptor 2,6,10,13,17,21-hexaaza[22]metacyclophane L presents a molecular architecture which enables recognition in aqueous solution of ATP, ADP and AMP through electrostatic, hydrogen bonding and pi-stacking interactions; electrostatic interactions occur between the polyammonium sites of L and the phosphate chain of the nucleosides, and pi-stacking interactions occur between the m-phenylene subunit incorporated in the receptor as a non-pendant integral part of the macrocyclic framework and the adenine ring of the nucleotides.