Tolerance is the key to understanding antimalarial drug resistance
Tolerance is the key to understanding antimalarial drug resistance
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DOI：
10.1016/j.pt.2005.12.011
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发表时间：
2006-02-01
影响因子：
9.6
通讯作者：
Watkins, WM
中科院分区：
文献类型：
--
作者：
Hastings, IM;Watkins, WM
抗疟药物耐药性的演变通常被认为是一个单阶段过程，其中寄生虫对药物完全耐药或完全敏感。然而，这并没有考虑到药物耐受性的重要中间阶段。耐药寄生虫被直接治疗人类宿主期间出现的高血清药物浓度杀死。然而，这些寄生虫可以在人群中传播，因为许多药物在治疗后持续很长时间，并且耐受寄生虫可以感染药物残留水平的人。完全敏感和完全耐药寄生虫之间的这一中间阶段对抗药性疟疾的演变具有深远的影响。
The evolution of antimalarial drug resistance is often considered to be a single-stage process in which parasites are either fully resistant or completely sensitive to a drug. However, this does not take into account the important intermediate stage of drug tolerance. Drug-tolerant parasites are killed by the high serum concentrations of drugs that occur during direct treatment of the human host. However, these parasites can spread in the human population because many drugs persist long after treatment, and the tolerant parasites can infect people in which there are residual levels of the drugs. This intermediate stage between fully sensitive and fully resistant parasites has far-reaching implications for the evolution of drug-resistant malaria.