Guidelines for the use of systemic glucocorticosteroids in the management of selected infections. Working Group on Steroid Use, Antimicrobial Agents Committee, Infectious Diseases Society of America.
Guidelines for the use of systemic glucocorticosteroids in the management of selected infections. Working Group on Steroid Use, Antimicrobial Agents Committee, Infectious Diseases Society of America.
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全身性糖皮质激素在治疗特定感染中的使用指南。
DOI：
--
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发表时间：
1992
影响因子：
6.4
通讯作者：
F. Laforce
中科院分区：
文献类型：
--
作者：
J. Mcgowan;P. Chesney;K. Crossley;F. Laforce
这是美国传染病学会（IDSA）抗菌药物委员会关于抗感染治疗问题的一系列报告中的一篇[1-4]。糖皮质激素（为方便起见，本声明的其余部分将称为类固醇）有许多治疗用途，包括治疗选定的传染病或其并发症。将给出在治疗某些感染时系统使用这些药物的指南。本研究未涉及类固醇的局部治疗，也未涉及使用类固醇治疗感染过程中的某些并发症（如肾病综合征[5]、颅内压升高或其他神经系统后遗症[6]、溶血[7]）。类固醇在许多器官系统中发挥主要的免疫抑制和抗炎作用，损害抗体产生和细胞介导的免疫，并影响免疫系统的许多细胞。T细胞被暂时隔离；类固醇明显破坏了它们的运动[9,10]。单核细胞的交通，包括从循环的出口，受到损害。淋巴细胞和单核吞噬细胞产生的大多数细胞因子受到抑制[I 1]；此外，细胞因子对某些靶细胞的作用也被阻断。类固醇治疗可短暂减少多形核炎症反应，降低外周血淋巴细胞、单核细胞、嗜酸性粒细胞和嗜碱性粒细胞计数。这些对细胞的影响在类固醇剂量下最为明显
This is one in a series of reports by the Antimicrobial Agents Committee of the Infectious Diseases Society of America (IDSA) that address issues in antiinfective therapy [1-4]. Glucocorticosteroids (which for convenience will be called steroids in the rest of this statement) have many therapeutic uses, including treatment of selected infectious diseases or their complications. Guidelines will be given for the systemic use of these agents in the treatment of certain infections. Topical therapy with steroids is not addressed, nor is use of steroids to treat certain complications of the infection process in general (e.g., nephrotic syndrome [5], elevated intracranial pressure or other neurologic sequelae [6], hemolysis [7]). Steroids exert major immunosuppressive and antiinflammatory effects in many organ systems [8], impairing antibody production and cell-mediated immunity and affecting many cells of the immune system. T cells are sequestered transiently; their movement is markedly disrupted by steroids [9, 10]. Monocyte traffic, including egress from the circulation, is impaired. The production of most cytokines by lymphocytes and mononuclear phagocytes is inhibited [I 1]; further, the effects of cytokines on some target cells is also blocked [12]. Steroid therapy transiently reduces polymorphonuclear inflammatory responses and decreases lymphocyte, monocyte, eosinophil, and basophil counts in peripheral blood. These effects on cells are most evident if steroid doses
糖皮质激素受体和作用。
DOI：
--
发表时间：
1990
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Munck,A;Mendel,DB;Smith,LI;Orti,E
通讯作者：
Orti,E
影响因子：
158.5
作者：
BERNARD, GR;LUCE, JM;BRIGHAM, KL
通讯作者：
BRIGHAM, KL
细菌性脑膜炎：病理生理学和治疗的最新进展。
影响因子：
39.2
作者：
Tunkel,AR;Wispelwey,B;Scheld,WM
通讯作者：
Scheld,WM