Autoimmune encephalitis update
Autoimmune encephalitis update
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DOI：
10.1093/neuonc/nou030
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发表时间：
2014-06-01
期刊：
影响因子：
15.9
通讯作者：
Rosenfeld, Myrna R.
中科院分区：
文献类型：
--
作者：
Dalmau, Josep;Rosenfeld, Myrna R.
癌症相关的免疫介导的中枢神经系统疾病是一个异质组。这些疾病包括典型的副肿瘤性神经系统疾病和最近描述的与神经元细胞表面或突触受体的抗体相关的自身免疫性脑炎，其发生与癌症相关或不相关。自身免疫性脑炎越来越被认为是各种严重和长期的神经精神综合征的原因。与对肿瘤治疗和免疫治疗反应不良的典型副肿瘤性疾病相反，自身免疫性脑炎通常对这些治疗有反应，患者可以完全或显著康复。由于早期治疗可以加速康复，减少残疾，并减少约20%病例的复发，因此认识到这些疾病的免疫发病机制非常重要。
Cancer-associated immune-mediated disorders of the central nervous system are a heterogeneous group. These disorders include the classic paraneoplastic neurologic disorders and the more recently described autoimmune encephalitis associated with antibodies to neuronal cell-surface or synaptic receptors that occur with and without a cancer association. Autoimmune encephalitis is increasingly recognized as the cause of a variety of neuropsychiatric syndromes that can be severe and prolonged. In contrast to the classic paraneoplastic disorders that are poorly responsive to tumor treatment and immunotherapy, autoimmune encephalitis often responds to these treatments, and patients can have full or marked recoveries. As early treatment speeds recovery, reduces disability, and decreases relapses that can occur in about 20% of cases, it is important that the immune pathogenesis of these disorders is recognized.