On the memory of a chronic illness.
On the memory of a chronic illness.
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DOI：
10.1126/sageke.2003.45.re8
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发表时间：
2003-11
期刊：
影响因子：
--
通讯作者：
P. Goldschmidt-Clermont;E. Peterson
中科院分区：
文献类型：
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作者：
P. Goldschmidt-Clermont;E. Peterson
老年人特别容易患病，但导致这种易感性的生物学机制尚不清楚。以动脉粥样硬化作为慢性疾病模型，我们回顾了最近在小鼠和人类中骨髓来源的血管修复系统的研究如何为年龄相关疾病的病因和潜在治疗提供新的见解。生物体在长期暴露于组织损伤后，天生具有有限的干细胞介导修复能力。一旦这种能力被耗尽，就会出现病理性炎症的循环，并导致明显的疾病表现。增强干细胞介导的修复系统可能提供一种治疗或预防许多与年龄有关的疾病的新方法。
The elderly are particularly susceptible to disease, yet the biological mechanisms that bring about this susceptibility remain unclear. Using atherosclerosis as a model chronic illness, we review how recent studies of bone marrow-derived vascular repair systems in mice and humans provide new insights into the causes and potential cures for age-related illness. Organisms are born with a finite capacity for stem cell-mediated repair after chronic exposure to tissue injury. Once that capacity is exhausted, a cycle of pathological inflammation ensues and leads to overt disease manifestations. Augmentation of stem cell-mediated repair systems may provide a novel means of treating or preventing many age-related illnesses.