Pleural migration of chrysotile fibers after intratracheal injection in rats.
Pleural migration of chrysotile fibers after intratracheal injection in rats.
复制标题
大鼠气管内注射后温石棉纤维的胸膜迁移。
DOI：
--
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
C. Boutin
中科院分区：
文献类型：
--
作者：
J. Viallat;F. Raybuad;M. Passarel;C. Boutin
经气管内注射UICC温石棉0.5 mg后，在1个月的时间间隔内处死大鼠，用生理盐水冲洗胸腔。样品通过透射电子显微镜进行鉴定、定量和温石棉纤维的测定。对照组大鼠注射生理盐水后未见纤维。实验大鼠到达胸膜腔的纤维大小和数量随时间变化，在第7天出现两个峰值（平均数量= 9.6 X 10）；平均长度= 1.3微米)和第21天（平均数量= 1.3 X 10(5)）；平均长度= 0.3微米)。这种变异与温石棉原纤维向胸膜的异质迁移是相容的。
After intratracheal injection of 0.5 mg of UICC chrysotile, rats were sacrificed at various time intervals over a 1-month period, and their pleural cavity washed with saline. Samples were examined by means of transmission electron microscopy for identification, quantitation, and sizing of chrysotile fibers. No fibers were found in control rats injected with saline. The size and quantity of fibers that reached the pleural cavity of test rats was time-dependent, with two peaks on day 7 (mean number = 9.6 X 10(4); mean length = 1.3 micron) and on day 21 (mean number = 1.3 X 10(5); mean length = 0.3 micron). Such variations are compatible with a heterogeneous migration of chrysotile fibrils toward the pleura.