Meat and ascorbic acid can promote Fe availability from Fe-phytate but not from Fe-tannic acid complexes
Meat and ascorbic acid can promote Fe availability from Fe-phytate but not from Fe-tannic acid complexes
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DOI：
10.1021/jf0518453
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发表时间：
2005-12-28
影响因子：
6.1
通讯作者：
Glahn, R
中科院分区：
文献类型：
--
作者：
Engle-Stone, R;Yeung, A;Glahn, R
本研究利用体外消化/Caco-2细胞模型，以确定所需的抗坏血酸（AA）和“肉因子”的水平，以促进铁与植酸（PA）或单宁酸（TA）络合吸收铁。AA从1：20：1（Fe：PA：AA）的摩尔比开始逆转PA对Fe吸收的抑制作用，但对与TA络合的Fe基本上没有影响。鱼也逆转了铁吸收的抑制PA，但不是由TA。TA和鱼降低总铁溶解度。铁在PA的存在下是高度可溶的。AA，但不是鱼，增加了可溶性铁的百分比为Fe 2+在这两种抑制剂的存在下。结果表明，植酸一铁是一种形式的铁，可用于吸收的吸收促进剂的存在下。相比之下，TA-Fe络合物在促进剂的存在下溶解度低得多并且不可用。
This study utilized an in vitro digestion/Caco-2 cell model to determine the levels of ascorbic acid (AA) and "meat factor" needed to promote Fe absorption from Fe complexed with phytic acid (PA) or tannic acid (TA). AA reversed the inhibition of Fe absorption by PA beginning at a molar ratio of 1:20:1 (Fe:PA:AA) but essentially had no effect on the Fe complexed with TA. Fish also reversed the inhibition of Fe uptake by PA but not by TA. TA and fish decreased total Fe solubility. Iron in the presence of PA was highly soluble. AA, but not fish, increased the percentage of soluble Fe as Fe2+ in the presence of both inhibitors. The results indicate that monoferric phytate is a form of Fe that can be available for absorption in the presence of uptake promoters. In contrast, a TA-Fe complex is much less soluble and unavailable in the presence of promoters.