Predicting growth and curve progression in the individual patient with adolescent idiopathic scoliosis: design of a prospective longitudinal cohort study.
Predicting growth and curve progression in the individual patient with adolescent idiopathic scoliosis: design of a prospective longitudinal cohort study.
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DOI：
10.1186/1471-2474-11-93
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发表时间：
2010-05-17
影响因子：
2.3
通讯作者：
Veldhuizen AG
中科院分区：
文献类型：
--
作者：
Busscher I;Wapstra FH;Veldhuizen AG
3-5%的青少年儿童患有脊柱侧凸，其中女性发病率更高。青少年特发性脊柱侧凸的治疗主要依赖于脊柱侧凸曲线的进展。在青春期，患者脊柱的快速生长与脊柱弯曲的进展有密切的关系。然而，到目前为止，还没有找到确切的方法来预测总身高青春期生长突增的时间和幅度，或特发性脊柱侧凸的曲线进展。本研究的目的是确定几个反映生长或剩余生长潜力的成熟度指标的预测价值，以预测青少年特发性脊柱侧凸个体患者总身高生长速度峰值的时间。此外，还评估了不同参数与个体脊柱侧凸患者曲线进展的相关性。这项前瞻性、纵向队列研究将纳入青少年特发性脊柱侧凸患者的常规护理。所有在格罗宁根大学医学中心门诊就诊的8 - 17岁青少年特发性脊柱侧凸（Cobb角bbb10度）新患者均被纳入本研究。每6个月随访一次。本研究将使用一种新的超低剂量x射线系统，可以进行全身x射线。几个成熟度指标被评估，如不同的体长尺寸，第二性征，手和手腕的骨骼年龄，肘部的骨骼年龄，里瑟氏征，三辐软骨的状态，以及棘旁肌肉活动的肌电比。所有维度的相关性将根据青春期生长突升的时间和脊柱侧弯曲线的进展来计算。算法将作出最佳的治疗策略，在个别患者的青少年特发性脊柱侧凸。这项研究将确定许多成熟度指标的价值，并将对其他临床医生治疗患有生长障碍的儿童有用。由于并非所有临床医生都有机会使用新的3D x线系统或有时间制作肌电图，例如，所有指标都将与特发性脊柱侧凸的全身高度和曲线进展的峰值生长速度的时间相关。因此，每个临床医生可以选择哪些指标可以在他们的实践中最好地使用。NTR2048
Scoliosis is present in 3-5% of the children in the adolescent age group, with a higher incidence in females. Treatment of adolescent idiopathic scoliosis is mainly dependent on the progression of the scoliotic curve. There is a close relationship between curve progression and rapid (spinal) growth of the patient during puberty. However, until present time no conclusive method was found for predicting the timing and magnitude of the pubertal growth spurt in total body height, or the curve progression of the idiopathic scoliosis. The goal of this study is to determine the predictive value of several maturity indicators that reflect growth or remaining growth potential, in order to predict timing of the peak growth velocity of total body height in the individual patient with adolescent idiopathic scoliosis. Furthermore, different parameters are evaluated for their correlation with curve progression in the individual scoliosis patient. This prospective, longitudinal cohort study will be incorporated in the usual care of patients with adolescent idiopathic scoliosis. All new patients between 8 and 17 years with adolescent idiopathic scoliosis (Cobb angle >10 degrees) visiting the outpatient clinic of the University Medical Center Groningen are included in this study. Follow up will take place every 6 months. The present study will use a new ultra-low dose X-ray system which can make total body X-rays. Several maturity indicators are evaluated like different body length dimensions, secondary sexual characteristics, skeletal age in hand and wrist, skeletal age in the elbow, the Risser sign, the status of the triradiate cartilage, and EMG ratios of the paraspinal muscle activity. Correlations of all dimensions will be calculated in relationship to the timing of the pubertal growth spurt, and to the progression of the scoliotic curve. An algorithm will be made for the optimal treatment strategy in the individual patient with adolescent idiopathic scoliosis. This study will determine the value of many maturity indicators and will be useful as well for other clinicians treating children with disorders of growth. Since not all clinicians have access to the presented new 3D X-ray system or have the time to make EMG's, for example, all indicators will be correlated to the timing of the peak growth velocity of total body height and curve progression in idiopathic scoliosis. Therefore each clinician can chose which indicators can be used best in their practice. NTR2048
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影响因子：
1.7
作者：
Rao, S;Joshi, S;Kanade, A
通讯作者：
Kanade, A
影响因子：
--
作者：
Karlberg, J;Kwan, CW;Albertsson-Wikland, K
通讯作者：
Albertsson-Wikland, K
DOI：
10.2106/00004623-200010000-00010
发表时间：
2000-10-01
影响因子：
5.3
作者：
Paley, D;Bhave, A;Bowen, JR
通讯作者：
Bowen, JR
影响因子：
5.2
作者：
Bull, RK;Edwards, PD;Hughes, IA
通讯作者：
Hughes, IA
DOI：
10.2106/00004623-200005000-00009
发表时间：
2000-05-01
影响因子：
5.3
作者：
Little, DG;Song, KM;Herring, JA
通讯作者：
Herring, JA