Site of action of exfoliative toxin in the staphylococcal scaled-skin syndrome.
Site of action of exfoliative toxin in the staphylococcal scaled-skin syndrome.
复制标题
剥脱性毒素在葡萄球菌鳞状皮肤综合征中的作用部位。
作者：
Clinton B. Lillibridge;M. E. Melish;Lowell A. Glasgow
本研究的目的是证明形态学相关的皮肤暴露于剥脱毒素来自活噬菌体组II葡萄球菌。人类感染这些葡萄球菌与猩红热样皮疹、全身剥脱或大疱性脓疱有关。
从组织学上看，注射剥脱性毒素的患者和动物的皮肤病变似乎无法区分。特征性的变化是表皮内颗粒细胞层的分裂。电子显微镜下，这种分裂似乎是由于破坏了细胞间接触区的正常附着结构（桥粒）。这种破坏可能与细胞外小球的消失有关，这些小球可能含有蛋白水解酶。
The purpose of this study was to demonstrate morphologic correlates of exposure of skin to exfoliative toxin derived from live phage group II staphylococci. Human infection with these staphylococci has been associated with scarlatiniform rash, generalized exfoliation, or bullous impetigo.
Histologically, the skin lesions in patients and animals injected with the exfoliative toxin appear indistinguishable. The characteristic change is an intraepidermal cleavage through the granular cell layer. Electron microscopically, this cleavage appears to result from disruption of otherwise normal attachment structures (desmosomes) through their intercellular contact area. This disruption may be related to disappearance of extracellular globules which are proposed possibly to contain proteolytic enzymes.