Low infectiousness of a wildlife host of Leishmania infantum:: the crab-eating fox is not important for transmission
Low infectiousness of a wildlife host of Leishmania infantum:: the crab-eating fox is not important for transmission
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DOI：
10.1017/s0031182002002238
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发表时间：
2002-11-01
期刊：
影响因子：
2.4
通讯作者：
Dye, C
中科院分区：
文献类型：
--
作者：
Courtenay, O;Quinnell, RJ;Dye, C
在巴西亚马逊河流域的一项纵向研究中，对食蟹狐狸Cerdocyon thous在婴儿利什曼原虫传播中的流行病学作用进行了评估。共37野生捕获的狐狸进行免疫学和临床监测，26只狐狸暴露于实验室菌落的白蛉载体Lutzommyia longipalpis，超过15个月的时间。总共78%（29/37）的狐狸至少有1次抗利什曼原虫1gG油血清阳性，38%（8/37）的狐狸经PCR和/或培养证实感染。点患病率分别为74%（血清学），15%（PCR）和26%（培养）。未观察到疾病进展体征。从44份饲料中解剖出1469只白蛉，无一只感染。保守估计，狐狸对传播的可能贡献为9%，而同域家犬为91%。这些结果表明，吃螃蟹的狐狸种群并没有保持独立于家犬的传播周期。这意味着他们不太可能将这种寄生虫引入没有利什曼病的狗群。
The epidemiological role of the crab-eating fox Cerdocyon thous in the transmission of Leishmania infantum is assessed in a longitudinal study in Amazon Brazil. A total of 37 wild-caught foxes were immunologically, and clinically monitored, and 26 foxes exposed to laboratory colonies of the sandfly vector Lutzommyia longipalpis, over a 15-month period. In total 78% (29/37) of foxes were seropositive for anti-Leishmania 1gG oil at least 1 occasion, and 38% (8/37) had infections confirmed by PCR and/or by culture. Point prevalences were 74% (serology), 15% (PCR), and 26% (culture). No Signs of progressive disease were observed. None of the foxes were infectious to the 1469 sandflies dissected from 44 feeds. A conservative estimate of the possible contribution of foxes to transmission was 9% compared to 91% by sympatric domestic dogs. These results show that crab-eating fox populations do not maintain a transmission cycle independently of domestic dogs. The implication is that they are unlikely to introduce the parasite into Leishmania-free dog populations.