p120 catenin reduction and cytoplasmic relocalization leads to dysregulation of E-cadherin in solid pseudopapillary tumors of the pancreas
p120 catenin reduction and cytoplasmic relocalization leads to dysregulation of E-cadherin in solid pseudopapillary tumors of the pancreas
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DOI：
10.1309/feyd99txc4lmyva5
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发表时间：
2008-07-01
影响因子：
3.5
通讯作者：
Serra, Stefano
中科院分区：
文献类型：
--
作者：
Chetty, Runjan;Jain, Dhanpat;Serra, Stefano
胰腺实性假乳头状瘤 (SPT) 具有特征性的形态和特征，并表现出一致的 β-连环蛋白异常和 E-钙粘蛋白缺失。细胞间粘附力的丧失被认为导致频繁的囊性变性和假乳头形成。 p120 调节 E-cadherin 并负责其降解。20 例组织微阵列和另外 9 例 SPT 的完整切片用 p120、β-catenin 和 E-cadherin 染色。所有29例均显示β-连环蛋白的细胞质和核染色、E-钙粘蛋白缺失、p120膜定位减少或缺失，但细胞质染色相反。在肿瘤的囊性和实性区域中观察到膜 p120 染色的丢失并重新定位到细胞质。这项研究表明 SPT 中的 p120 表达异常，E-钙粘蛋白的丢失可能是 p120 丢失或减少的结果。 E-钙粘蛋白基因的畸变和其他改变不太可能是 SPT 中 E-钙粘蛋白丢失的原因。
Solid pseudopapillary tumors (SPTs) of the pancreas have characteristic morphologic, features and show consistent beta-catenin abnormalities and loss of E-cadherin protein. The loss of cell-to-cell adhesion is thought to contribute to frequent cystic degeneration and pseudopapillae formation. p120 regulates E-cadherin and is responsible for its degradation.A tissue microarray of 20 cases and whole sections from another 9 cases of SPT were stained with p120, beta-catenin, and E-cadherin. All 29 cases showed cytoplasmic and nuclear staining for beta-catenin, loss of E-cadherin, and decrease or loss of p120 membrane localization but cytoplasmic staining instead. Loss of membrane p120 staining with relocalization to the cytoplasm was seen in cystic and solid areas of the tumors.This study indicates that p120 expression in SPTs is abnormal and loss of E-cadherin is probably consequent on p120 loss or decrease. Aberrations and other alterations of the E-cadherin gene are unlikely to be responsible for the loss of E-cadherin in SPTs.