Stroke and Cancer The Importance of Cancer-Associated Hypercoagulation as a Possible Stroke Etiology
Stroke and Cancer The Importance of Cancer-Associated Hypercoagulation as a Possible Stroke Etiology
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DOI：
10.1161/strokeaha.112.658625
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发表时间：
2012-11-01
期刊：
影响因子：
8.3
通讯作者：
Fatar, Marc
中科院分区：
文献类型：
--
作者：
Schwarzbach, Christopher J.;Schaefer, Anke;Fatar, Marc
背景和目的：迄今为止，癌症相关高凝状态作为癌症患者可能的卒中病因的重要性受到的关注相对较少。最近的一项研究表明，癌症相关的高凝状态可能是特别重要的，在没有传统的中风mechanism. Methods的情况下，我们确定了缺血性中风的患者顺序承认我们的中风中心，从2002年至2011年的额外诊断活动性和恶性癌症。通过使用我们前瞻性收集的卒中、MRI和实验室数据库，将卒中的病因和危险因素、癌症类型、深静脉血栓形成/肺栓塞、d-二聚体水平和弥散加权成像病变模式与年龄和性别匹配的对照组进行比较。癌症患者与传统的中风病因和患者与一个身份不明和/或癌症相关的中风病因进行了分析separately. Results-140例癌症患者和140名对照组。不明原因卒中（P
\ Background and Purpose-The importance of cancer-associated hypercoagulability as a possible stroke etiology in patients with cancer has received relatively little attention to date. A recent study has suggested that cancer-associated hypercoagulation may be of special importance in the absence of conventional stroke mechanisms.Methods-We identified patients with ischemic stroke sequentially admitted to our stroke center with the additional diagnosis of active and malignant cancer from 2002 to 2011. By using our prospectively collected stroke, MRI, and laboratory data banks, the etiology and risk factors of stroke, types of cancer, deep vein thrombosis/pulmonary embolism, d-dimer levels, and diffusion-weighted imaging lesion patterns were compared to an age-and sex-matched control group. Patients with cancer with a conventional stroke etiology and patients with an unidentified and/or cancer-associated stroke etiology were analyzed separately.Results-One hundred forty patients with cancer and 140 control subjects were included. Unidentified stroke (P