A case-control study of urinary concentrations of bisphenol A, bisphenol F, and bisphenol S and the risk of papillary thyroid cancer.
A case-control study of urinary concentrations of bisphenol A, bisphenol F, and bisphenol S and the risk of papillary thyroid cancer.
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DOI：
10.1016/j.chemosphere.2022.137162
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发表时间：
2022-11
期刊：
影响因子：
8.8
通讯作者：
Lei Zhang;Jiahuai Zhang;S. Fan;Yuxin Zhong;Jingguang Li;Yun-feng Zhao;Song Ni;Jiaying Liu;Yongning Wu
中科院分区：
文献类型：
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作者：
Lei Zhang;Jiahuai Zhang;S. Fan;Yuxin Zhong;Jingguang Li;Yun-feng Zhao;Song Ni;Jiaying Liu;Yongning Wu
甲状腺癌(TC)，尤其是乳头状甲状腺癌(PTC)的发病率在全球范围内急剧上升。虽然一些内分泌干扰物与肿瘤过程有关，但人类接触双酚类似物与TC风险之间的关联仍不清楚。本病例对照研究探讨了尿双酚A、双酚F和双酚S与PTC发病风险之间的关系。在调整混杂因素和肌酐标准化因素后，在总人口中，BPF与BPF呈显著正相关(优势比[OR]=11.80，95%可信区间[CI]=91.27-2.54)，而BPA(OR=30.38，95%CI=0.19-0.77)和BPS(OR=60.63，95%CI=60.43-0.93)呈负相关。然而，在按年龄和吸烟进行分层后，仅在不吸烟的女性中保留了统计学意义，这表明接触BPF对PTC风险的不利影响，特别是在女性中。这些发现需要在进一步的研究中重复和证实。
The incidence of thyroid cancer (TC), especially papillary thyroid cancer (PTC), has dramatically increased globally. Whereas some endocrine disruptors have been linked to neoplastic processes, the associations between human exposure to bisphenol analogs and the risk of TC remain unclear. This present case-control study examined the associations between the urinary concentrations of bisphenol A (BPA) and other bisphenols, namely bisphenol F (BPF) and bisphenol S (BPS), and the risk of PTC. After adjusting for confounders and creatinine standardization, significantly positive associations were observed for BPF (odds ratio [OR] = 1.80, 95% confidence interval [CI] = 1.27–2.54), but negative associations observed for BPA (OR = 0.38, 95% CI = 0.19–0.77) and BPS (OR = 0.63, 95% CI = 0.43–0.93), in the total population. However, after stratification by age and smoking, statistical significance was retained only in non-smoking women, suggesting the adverse effects of BPF exposure on PTC risk, especially in women. These findings require replication and confirmation in further research.