Differentiation of mesodermal cells from pluripotent stem cells
Differentiation of mesodermal cells from pluripotent stem cells
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DOI：
10.1007/s12185-010-0518-8
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发表时间：
2010-04-01
影响因子：
2.1
通讯作者：
Era, Takumi
中科院分区：
文献类型：
--
作者：
Kitagawa, Michinori;Era, Takumi
大量研究已充分证明了胚胎干细胞的多能性，这些研究显示其可诱导分化为所需的细胞类型，这些细胞类型不仅可用于基础研究，还可用于医学应用。从移植的角度来看，从胚胎干细胞诱导中胚层细胞，特别是血细胞是值得注意的，并且这种诱导方法在过去几年中得到了改进，并且有了更明确的培养条件。同时，从体细胞产生诱导多能干细胞开启了自体移植的可能性。事实上，越来越多的报告表明，使用与胚胎干细胞相同的方法可以从诱导多能干细胞中分化出几种中胚层细胞。本文综述了中胚层细胞从胚胎干细胞和诱导多能干细胞分化方面的最新进展。
The pluripotency of embryonic stem cells has been well demonstrated by a vast variety of studies showing the induction of differentiation into desired cell types that have the potential to be used not only in basic studies but also in medical applications. The induction of mesodermal cells, especially blood cells, from embryonic stem cells is notable from the point of view of transplantation, and the methods for this induction have improved over the last few years, with more defined culture conditions in place. Concurrently, the generation of induced pluripotent stem cells from somatic cells opens the possibility of autologous transplantation. In fact, there are a growing number of reports demonstrating that several mesodermal cells can be differentiated from induced pluripotent stem cells using the same methods used for embryonic stem cells. This review summarizes recent advances in the differentiation of mesodermal cells from embryonic stem cells and induced pluripotent stem cells.