Mesenchymal stromal cells from umbilical cord blood.
Mesenchymal stromal cells from umbilical cord blood.
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DOI：
10.2174/157488807782793763
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发表时间：
2007-12-01
影响因子：
2.7
通讯作者：
Kluter, Harald
中科院分区：
文献类型：
--
作者：
Bieback, Karen;Kluter, Harald
间充质基质细胞（MSC）是细胞疗法的关键候选者。虽然大多数治疗应用集中在成人骨髓来源的MSC，越来越多的证据表明，MSC存在于广泛的组织中。脐带血（CB）已被证明是造血干细胞的一个有价值的来源，但其治疗潜力超出了造血成分，这表明在实体器官中也有再生潜力。有证据表明，其他干细胞或祖细胞群体，如MSC，存在于CB中，这可能是造成这些影响的原因。许多不同的干细胞和祖细胞群体已经被假定具有从胚胎样祖细胞到谱系定向祖细胞的潜能。基于这些令人困惑的数据，本文综述了一个人CB来源的，塑料粘附成纤维细胞样人口表达类似的特点，骨髓来源的MSC。它特别集中于分离和扩增的概念，比较表型与骨髓来源的MSC，描述分化能力，最后在再生医学，基质支持，免疫调节和基因治疗方面的治疗潜力。
Mesenchymal Stromal Cells (MSC) are key candidates for cellular therapies. Although most therapeutic applications have focused on adult bone marrow derived MSC, increasing evidence suggests that MSC are present within a wide range of tissues. Umbilical cord blood (CB) has been proven to be a valuable source of hematopoietic stem cells, but its therapeutic potential extends beyond the hematopoietic component suggesting regenerative potential in solid organs as well. There is evidence that other stem or progenitor populations, such as MSC, exist in CB which might be responsible for these effects. Many different stem and progenitor cell populations have been postulated with potential ranging from embryonic like to lineage-committed progenitor cells. Based on the confusing data, this review focuses on a human CB derived, plastic adherent fibroblastoid population expressing similar characteristics to bone marrow derived MSC. It concentrates especially on concepts of isolation and expansion, comparing the phenotype with bone marrow derived MSC, describing the differentiation capacity and finally in the last the therapeutic potential with regard to regenerative medicine, stromal support, immune modulation and gene therapy.