Ion transport across isolated antral mucosa of the rabbit.
Ion transport across isolated antral mucosa of the rabbit.
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离子传输穿过兔子的孤立的胃窦粘膜。
DOI：
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发表时间：
1976
影响因子：
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通讯作者：
J. Schwartz
中科院分区：
文献类型：
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作者：
D. Fromm;J. Schwartz
钠，氯，钾同位素通量测定在短路条件下通过离体胃窦粘膜。HCO 3通量也测量与同位素和/或pH-统计方法。观察到所有四种离子的净分泌。HCO 3分泌是由于需要代谢能量的透壁过程。未观察到内源性HCO 3的分泌，并且HCO 3的单向粘膜-浆膜通量可以忽略不计。HCO 3分泌和单向粘膜-浆膜Cl通量之间似乎存在密切关系，但单向浆膜-粘膜通量或单向Na通量之间未观察到关系。大量的HCO 3分泌是独立的单向氯通量，但有一小部分的HCO 3运输是依赖于单向氯运输。然而，HCO 3运输是没有可测量的净氯（和钠）运输本身的抑制的影响。
Isotopic fluxes of Na, Cl, and K were measured across isolated antral mucosa under short-circuit conditions. HCO3 fluxes were also measured with either isotopic and/or pH-stat methods. Net secretion of all four ions was observed. HCO3 secretion is due to a transmural process requiring metabolic energy. Secretion of endogenous HCO3 was not observed, and the unidirectional mucosal-to-serosal flux of HCO3 was negligible. There appears to be a close relationship between HCO3 secretion and the unidirectional mucosal-to-serosal Cl flux, but not relationships were observed between the unidirectional serosal-to-mucosal flux or either unidirectional Na flux. The bulk of HCO3 secretion is independent of the unidirectional Cl fluxes, but there is a fraction of HCO3 transport that is dependent on unidirectional Cl transport. However, HCO3 transport is not measurably influenced by inhibition of net Cl (and Na) transport per se.