Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ.
Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ.
复制标题
热休克蛋白 hsp40（细菌 DnaJ 的人类同源物）的 cDNA 克隆。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
Kenzo Ohtsuka
中科院分区：
文献类型：
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作者：
Kenzo Ohtsuka
We here isolated and characterized a cDNA clone encoding 40-kDa heat-shock protein hsp40 from cDNA expression library of human placenta by immunoscreening with anti-hsp40 antibody. N-terminal amino acid sequence (48 residues) deduced from the base sequence was completely identical to that of hsp40 purified from HeLa cells. Deduced amino acid sequence of the cDNA is homologous to bacterial DnaJ heat-shock protein and its homologues in yeast such as SCJ1, YDJ1(MAS5), SIS1, SEC63 and Zuotin. Nucleotide sequence identity between hsp40 and HDJ1 (another human DnaJ homologue) is more than 98%, suggesting that these two proteins are the same gene product.
