Feedback circuitry within a song-learning pathway.
Feedback circuitry within a song-learning pathway.
复制标题
歌曲学习路径中的反馈电路。
DOI：
10.1073/pnas.92.11.5139
复制
发表时间：
1995
影响因子：
11.1
通讯作者：
Nottebohm,F
中科院分区：
文献类型：
--
作者：
Vates,GE;Nottebohm,F
鸟类的鸣叫系统由多个神经通路组成。其中之一，前脑通路，对于斑胸草雀习得的歌曲是必要的，但对于产生习得的歌曲却不是必需的。研究表明，前脑通路依次连接以下核团：高位发声中心、副嗅叶X区、丘脑背外侧核内侧部分、前新纹状体外侧巨细胞核（IMAN）和古纹状体强健核（RA）。我们现在在斑胸草雀 (Taeniopygia guttata) 中发现，投射到 RA 的 IMAN 细胞也投射到 X 区，在前脑通路内形成反馈回路。 IMAN 投射到 X 区的轴突末端形成有粘性且不同的域。在 X 区的子区域中少量注射示踪剂会回填 IMAN 中空间受限的细胞子集，进而将投影发送到排列在水平层中的 RA，这可能对应于其他人所展示的声道肌肉的功能表示。我们从数据中推断出，整个前脑通路都存在肌位表征。此外，我们建议通过 IMAN 的投影将区域 X 分割成更小的域，突出显示 X 内的功能架构，该架构可能对应于运动控制单元、歌曲声学特征的表示，或两者对应。
The song system of birds consists of several neural pathways. One of these, the anterior forebrain pathway, is necessary for the acquisition but not for the production of learned song in zebra finches. It has been shown that the anterior forebrain pathway sequentially connects the following nuclei: the high vocal center, area X of lobus parolfactorius, the medial portion of the dorsolateral thalamic nucleus, the lateral magnocellular nucleus of anterior neostriatum (IMAN), and the robust nucleus of the archistriatum (RA). We now show in zebra finches (Taeniopygia guttata) that IMAN cells that project to RA also project to area X, forming a feedback loop within the anterior forebrain pathway. The axonal endings of the IMAN projection into area X form cohesive and distinct domains. Small injections of tracer in subregions of area X backfill a spatially restricted subset of cells in IMAN, that, in turn, send projections to RA that are arranged in horizontal layers, which may correspond to the functional representation of vocal tract muscles demonstrated by others. We infer from our data that there is a myotopic representation throughout the anterior forebrain pathway. In addition, we suggest that the parcellation of area X into smaller domains by the projection from IMAN highlights a functional architecture within X, which might correspond to units of motor control, to the representation of acoustic features of song, or both.