Autosomal genes involved in mammalian primary sex determination.
Autosomal genes involved in mammalian primary sex determination.
复制标题
参与哺乳动物初级性别决定的常染色体基因。
DOI：
10.1098/rstb.1988.0118
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Eicher,EM
中科院分区：
文献类型：
--
作者：
Eicher,EM
从20世纪50年代末和60年代初的发现开始，不断有证据支持这样的假设，即哺乳动物的Y染色体携带一种基因，可以诱导XY个体未分化的胎儿性腺发育为睾丸。最近，从人类Y染色体中分离出一个DNA序列，它似乎是Y连锁的睾丸决定基因，并且在识别与Y连锁的睾丸决定基因(TDY)相互作用的启动睾丸形成的基因方面也取得了进展。这些基因座已经在特定的小鼠种群中被发现，这些小鼠在位于17号染色体上的T基因座上携带突变的Thpor Torl等位基因，以及在涉及将Y染色体从两个家鼠群体转移到特定近交系小鼠基因组的杂交中。这两种情况下的数据都支持这样的假设，即有几个基因座参与了睾丸决定，这些基因的异常相互作用扰乱了睾丸决定的启动，导致了XY个体卵巢组织的发育。
Beginning with findings made during the late 1950s and early 1960s, evidence continues to accumulate in support of the hypothesis that the mammalian Y chromosome carries a gene that induces the undifferentiated foetal gonad in XY individuals to develop as a testis. Recently a DNA sequence has been isolated from the human Y chromosome that appears to be the hypothesized Y-linked testis-determining gene, and advances have also been made toward identifying genes that interact with the Y-linked testis-determining (Tdy) gene to initiate testis formation. These loci have been identified in specific stocks of mice carrying the mutant Thpor Torlallele at the T locus located on chromosome 17, and in crosses involving the transfer of a Y chromosome from two populations ofMus domesticusinto the genomes of specific inbred strains of mice. The data in both cases support the hypothesis that there are several loci involved in testis determination and that abnormal interaction of these loci disrupts initiation of testis determination, resulting in development of ovarian tissue in XY individuals.