Phenolics from commercialized grape extracts prevent early atherosclerotic lesions in hamsters by mechanisms other than antioxidant effect
Phenolics from commercialized grape extracts prevent early atherosclerotic lesions in hamsters by mechanisms other than antioxidant effect
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DOI：
10.1021/jf040125d
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发表时间：
2004-08-11
影响因子：
6.1
通讯作者：
Rouanet, JM
中科院分区：
文献类型：
--
作者：
Auger, C;Gérain, P;Rouanet, JM
本研究的目的是评估市售富含酚类的葡萄籽提取物（ExGrape seeds，EGS；葡萄籽提取物，GSE）和果渣（ExGrape Total，EGT）对胆固醇喂养的仓鼠的抗动脉粥样硬化作用，并研究可能的作用机制。这些提取物以中等剂量喂养，模仿每餐两杯红酒，降低了血浆胆固醇（平均-11%），但不影响仓鼠的血浆抗氧化能力。这些提取物可将主动脉粥样硬化的发生率降低 68% (EGS)、63% (EGT) 和 34% (GSE)。在其他地方，在使用大鼠主动脉环的离体实验中，EGS (7 μg/mL) 诱导 77% 的内皮依赖性舒张，而 EGT 和 GSE (30 μg/mL) 分别诱导 84% 和 72%。这些结果表明，葡萄籽和果渣中的酚类提取物有利于通过间接机制抑制动脉粥样硬化。
The aim of this study was to evaluate the antiatherosclerotic effect of commercially available phenolic-rich extracts from grape seeds (ExGrape seeds, EGS; grape seed extract, GSE) and marc (ExGrape total, EGT) in cholesterol-fed hamsters and to investigate possible operating mechanisms. These extracts fed at a moderate dose mimicking two glasses of red wine per meal reduced plasma cholesterol (-11% on average) but did not affect plasma antioxidant capacity of hamsters. The extracts prevented the development of aortic atherosclerosis by 68% (EGS), 63% (EGT), and 34% (GSE). Elsewhere, in an ex vivo experiment using rat aortic rings, EGS (7 mug/mL) induced 77% endothelium-dependent relaxation, whereas EGT and GSE (30 mug/mL) induced 84 and 72%, respectively. These results suggests that phenolic extracts from grape seeds and marc are beneficial in inhibiting atherosclerosis by indirect mechanism(s).