Dynapenia and Aging: An Update
Dynapenia and Aging: An Update
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DOI：
10.1093/gerona/glr010
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发表时间：
2012-01-01
影响因子：
5.1
通讯作者：
Clark, Brian C.
中科院分区：
文献类型：
--
作者：
Manini, Todd M.;Clark, Brian C.
2008年，我们发表了一篇文章，认为与年龄相关的肌肉力量丧失只能部分解释肌肉质量的减少，而其他生理因素可以解释老年人的肌肉无力(Clark BC，Manini TM)。骨质疏松症=/=厌食症。J Gerontol生物科学和医学科学。2008年；63：829-834)。因此，我们建议对这些事件(力量和质量损失)进行独立的定义，让术语“石棺减少”在最初的上下文中用来描述与年龄相关的肌肉质量损失。随后，我们创造了术语“动症”来描述与年龄相关的肌肉力量和力量的丧失。这篇文章将给出关于月经周期的生物学和临床文献的更新-服务于最好地综合这一翻译主题。此外，我们还提出了一种定义经期的有效决策算法。该算法专门用于使用年龄、危险因素的存在或不存在、握力筛查和膝关节伸展力量测试来筛查和定义月经迟缓。对单一风险因素的定义，如月经过少，将为建立身体残疾的复杂病因的风险概况提供信息。因此，这种方法模拟了心血管疾病风险概况的发展，包括高胆固醇血症、高血压、高血糖等因素。由于缺乏数据，工作决策算法仍有待充分开发和评估。然而，这些努力有望提供对月经迟缓在老年人身体功能丧失和残疾风险增加中所起作用的具体理解。
In 2008, we published an article arguing that the age-related loss of muscle strength is only partially explained by the reduction in muscle mass and that other physiologic factors explain muscle weakness in older adults (Clark BC, Manini TM. Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci. 2008;63:829-834). Accordingly, we proposed that these events (strength and mass loss) be defined independently, leaving the term "sarcopenia" to be used in its original context to describe the age-related loss of muscle mass. We subsequently coined the term "dynapenia" to describe the age-related loss of muscle strength and power. This article will give an update on both the biological and clinical literature on dynapenia-serving to best synthesize this translational topic. Additionally, we propose a working decision algorithm for defining dynapenia. This algorithm is specific to screening for and defining dynapenia using age, presence or absence of risk factors, a grip strength screening, and if warranted a test for knee extension strength. A definition for a single risk factor such as dynapenia will provide information in building a risk profile for the complex etiology of physical disability. As such, this approach mimics the development of risk profiles for cardiovascular disease that include such factors as hypercholesterolemia, hypertension, hyperglycemia, etc. Because of a lack of data, the working decision algorithm remains to be fully developed and evaluated. However, these efforts are expected to provide a specific understanding of the role that dynapenia plays in the loss of physical function and increased risk for disability among older adults.