PRESENCE OF RIBONUCLEOTIDES IN MATURE CLOSED CIRCULAR MITOCHONDRIAL-DNA
PRESENCE OF RIBONUCLEOTIDES IN MATURE CLOSED CIRCULAR MITOCHONDRIAL-DNA
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DOI：
10.1073/pnas.70.12.3339
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发表时间：
1973-01-01
影响因子：
11.1
通讯作者：
VINOGRAD, J
中科院分区：
文献类型：
--
作者：
GROSSMAN, LI;WATSON, R;VINOGRAD, J
小鼠和HeLa细胞的线粒体DNA被碱性和鸡胚核糖核酸酶H切割。已得出结论，核糖核苷酸存在于闭环双链体中。在pH 13.0的RNA和线粒体DNA的断裂率的比较研究表明，有不超过10个核糖核苷酸的线粒体DNA的主要部分。
Mitochondrial DNA from mouse and HeLa cells is nicked by alkali and chick-embryo ribonuclease H. It has been concluded that ribonucleotides are present in the closed-circular duplex. A comparative study of the scission rates at pH 13.0 of RNA and of mitochondrial DNAs indicates that there are no more than 10 ribonucleotides in the major fraction of the mitochondrial DNAs.