Anti-inflammatory activity of the non-peptidyl low molecular weight radical scavenger IAC in carrageenan-induced oedema in rats
Anti-inflammatory activity of the non-peptidyl low molecular weight radical scavenger IAC in carrageenan-induced oedema in rats
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DOI：
10.1111/j.2042-7158.2010.01233.x
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发表时间：
2011-03-01
影响因子：
3.3
通讯作者：
Baraldi, Mario
中科院分区：
文献类型：
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作者：
Corsi, Lorenzo;Zavatti, Manuela;Baraldi, Mario
在这项研究中，我们研究了非肽基低分子量自由基清除剂（IAC）在急性和慢性炎症动物模型中的抗炎活性。（10、25、50 mg/kg）在大鼠中测试了对随后的炎症和毒性攻击的相关行为反应，例如通过足底内注射角叉菜胶诱导后爪水肿和通过皮下植入棉球诱导的肉芽肿。此外，在不存在和存在角叉菜胶诱导的炎症的情况下，在用IAC（50 mg/kg）处理（或不处理）的动物中测试几种细胞因子的血清水平。此外，IAC下调白细胞介素（IL）2和IL 6的血清水平显着，而它增加了血清浓度的IL 1 α和glutathione.ConclusionAlthough它仍有待阐明是否IAC的抗氧化性能是直接负责的测试细胞因子的调制，这些结果表明IAC是一个可能的候选人一种新型的抗炎化合物。
ObjectiveIn this research we investigated the anti-inflammatory activity of a non-peptidyl low molecular weight radical scavenger (IAC) in an acute and chronic animal model of inflammation.MethodsFor this purpose the effect of IAC (10, 25, 50 mg/kg) was tested in rats on the associated behavioral responses to subsequent inflammatory and noxious challenges, such as hind paw oedema induced by intra-plantar injection of carrageenan and granuloma induced by subcutaneous implant of a cotton pellet, using indometacin (2.5 mg/kg) as reference drug. Moreover, the serum level of several cytokines was tested in the animal treated (or not) with IAC (50 mg/kg) both in the absence and presence of carrageenan-induced inflammation.Key findingsIAC showed a significant anti-inflammatory activity in both in acute and chronic models of inflammation. In addition IAC down regulated significantly the serum levels of interleukin (IL) 2 and IL6 whereas it increased the serum concentration of IL1 alpha and glutathione.ConclusionAlthough it remains to be elucidated whether or not the antioxidant property of IAC is directly responsible for the modulation of the tested cytokines, these results suggest IAC to be a possible candidate for a novel anti-inflammatory compound.