Mechanical Strength and Rheological Properties of Tissue Adhesives With Regard to Colorectal Anastomosis An Ex Vivo Study
Mechanical Strength and Rheological Properties of Tissue Adhesives With Regard to Colorectal Anastomosis An Ex Vivo Study
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DOI：
10.1097/sla.0000000000000599
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发表时间：
2015-02-01
影响因子：
9
通讯作者：
Lange, Johan Frederik
中科院分区：
文献类型：
--
作者：
Vakalopoulos, Konstantinos Aristotelis;Wu, Zhouqiao;Lange, Johan Frederik
目的：在结直肠吻合术的临床相关测试装置中比较现有组织粘合剂的机械强度和流变性。背景：对组织粘合剂在应用后的机械强度知之甚少。此外，流变分析对于理解机械性能和解释粘合剂之间的差异可能很重要。这项研究提供了关于结直肠粘附性的一系列组织粘合剂的机械强度和流变学的新数据。方法：包括 12 种手术组织粘合剂：4 种氰基丙烯酸酯粘合剂 (CA)、2 种纤维蛋白胶 (FG)、3 种聚乙二醇 (PEG) 粘合剂和 3 种白蛋白基 (AB) 粘合剂。将管状大鼠结肠段粘在一起。测量拉伸（T）、剪切（S）和剥离（P）强度。还评估了剪切储能 (G') 和剪切损失 (G'') 模量。 结果：CA 粘合剂比 AB 更强（T：P = 0.017；S：P = 0.064；P：P < 0.001），而 AB 又比 PEG 更强（T：P < 0.001；S：P < 0.001；P：P = 0.018）。 PEG 的剪切强度强于 FG（P = 0.013），并且拉伸强度和剥离强度相当（P > 0.05）。 CA 的组内变异最小。所进行的测试之间的机械强度密切相关。对于所有组合的粘合剂，流变特性（G' 和 G''）与机械强度密切相关。结论：CA 粘合剂在机械强度方面是最强且最均匀的组。水凝胶（FG、AB）是异质的，机械强度低于 CA。 FG 是机械性能最弱的粘合剂。流变特性与机械强度相关，可能有助于预测机械性能。
Objective: To compare mechanical strength and rheology of existing tissue adhesives in a clinically relevant test setup with regard to colorectal anastomosis.Background: Little is known on the mechanical strength of tissue adhesives directly after application. Furthermore, rheological profiling may be important in understanding mechanical performance and explaining differences between adhesives. This study provides new data on the mechanical strength and rheology of a comprehensive list of tissue adhesives with regard to colorectal adhesiveness.Methods: Twelve surgical tissue adhesives were included: 4 cyanoacrylate adhesives (CA), 2 fibrin glues (FG), 3 polyethylene glycol (PEG) adhesives, and 3 albumin-based (AB) adhesives. Tubular rat colonic segments were glued together. Tensile (T), shear (S), and peel (P) strength were measured. Shear storage (G') and shear loss (G '') moduli were also evaluated.Results: CA adhesives were stronger than AB (T: P = 0.017; S: P = 0.064; P: P < 0.001), which, in turn, were stronger than PEG (T: P < 0.001; S: P < 0.001; P: P = 0.018). PEG were stronger than FG for shear (P = 0.013) and comparable for tensile and peel strength (P > 0.05). Within-group variation was smallest for CA. Mechanical strength correlated strongly between performed tests. Rheological properties (G' and G '') correlated strongly with mechanical strength for all adhesives combined.Conclusions: CA adhesives are the strongest and most homogenous group in terms of mechanical strength. Hydrogels (FG, AB) are heterogeneous, with lower mechanical strength than CA. FG are mechanically the weakest adhesives. Rheological profiles correlate to mechanical strength and may be useful for predicting mechanical performance.