Copper-catalyzed trifluoromethyl thiolation--mild and efficient synthesis of trifluoromethyl thioethers.
Copper-catalyzed trifluoromethyl thiolation--mild and efficient synthesis of trifluoromethyl thioethers.
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DOI：
10.1002/chem.201302692
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
M. Rueping;Nikita V. Tolstoluzhsky;P. Nikolaienko
中科院分区：
文献类型：
--
作者：
M. Rueping;Nikita V. Tolstoluzhsky;P. Nikolaienko
温和硫磺：以易得的二、三、四取代乙烯基碘为原料，合成乙烯基三氟甲基硫醚的一般方法被开发出来。在与CuSCF3的反应中使用了多种底物，以在较短的反应时间内高产率地得到相应的产物，并且保持了初始的E/Z异构体比。此外，还开发了铜催化的三氟甲基硫醚反应体系。
Mild-mannered sulfur: A general method for the synthesis of vinyl trifluoromethyl thioethers starting from readily available di-, tri-, and tetrasubstituted vinyl iodides was developed. A wide variety of substrates were applied in the reaction with CuSCF3 to give the corresponding products in high yields, within short reaction times, with retention of the initial E/Z isomer ratio. In addition, a copper-catalyzed trifluoromethyl thioether protocol has been also developed.