Microbiome and pancreatic cancer: A comprehensive topic review of literature.
Microbiome and pancreatic cancer: A comprehensive topic review of literature.
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DOI：
10.3748/wjg.v23.i10.1899
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发表时间：
2017-03-14
影响因子：
4.3
通讯作者：
Von Hoff D
中科院分区：
文献类型：
--
作者：
Ertz-Archambault N;Keim P;Von Hoff D
回顾与胰腺癌相关的微生物组改变，其在诊断、风险评估和对疾病预后的影响方面的潜在效用。通过来自PubMed、MEDLINE和Web of Science的全方位主题综述进行了全面的文献综述。最后一次搜索是在2016年10月。与健康人群相比，胰腺癌患者的口腔、肠道和胰腺组织等几个身体部位存在着不同的微生物群变化。非侵入性筛查策略的先导性研究的成功为将来在早期诊断中的翻译应用和了解与疾病预防相关的可改变的危险因素提供了进一步的研究。其他肿瘤类型的临床前研究表明，微生物组操作提供了有利地改变癌症对现有治疗方案的反应并提高存活率的机会。
To review microbiome alterations associated with pancreatic cancer, its potential utility in diagnostics, risk assessment, and influence on disease outcomes. A comprehensive literature review was conducted by all-inclusive topic review from PubMed, MEDLINE, and Web of Science. The last search was performed in October 2016. Diverse microbiome alterations exist among several body sites including oral, gut, and pancreatic tissue, in patients with pancreatic cancer compared to healthy populations. Pilot study successes in non-invasive screening strategies warrant further investigation for future translational application in early diagnostics and to learn modifiable risk factors relevant to disease prevention. Pre-clinical investigations exist in other tumor types that suggest microbiome manipulation provides opportunity to favorably transform cancer response to existing treatment protocols and improve survival.