Fetal programming - Prenatal origins of health and illness
Fetal programming - Prenatal origins of health and illness
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DOI：
10.1111/j.1467-8721.2008.00544.x
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发表时间：
2008-02-01
影响因子：
7.2
通讯作者：
Lubach, Gabriele R.
中科院分区：
文献类型：
--
作者：
Coe, Christopher L.;Lubach, Gabriele R.
对幼年动物和人类的研究已经证明了胎儿阶段作为正常发育的形成期的关键重要性。然而，当我们试图阐明健康和疾病的起源时，这些发现的意义并不总是被纳入我们的思维中。这不仅是因为婴儿还在子宫里时，就会对母亲的状态和突出的环境事件做出反应。这种刺激和启动似乎对于引导神经、内分泌和免疫系统的最佳成熟至关重要。产前生活中的经历也规划了成年后管理生理的调节设置点。在这个可延展的成熟阶段，这些生物过程应该被视为灵活的“学习系统”，它引导着健康的发展轨迹，或者使其偏离病理的轨道。我们对婴儿灵长类动物的研究表明，它们的免疫反应能力、某些大脑区域的结构和活动，以及行为和情感反应的许多方面，都受到母亲怀孕条件的强烈影响。
Research on young animals and humans has demonstrated the critical importance of the fetal stage as a formative period in normal development. However, the significance of these findings has not always been incorporated into our thinking when trying to elucidate the origins of health and disease. It is not only that babies react to the state of the mother and to salient environmental events while still in the uterus. This stimulation and priming seems to be essential for guiding the optimal maturation of the nervous, endocrine, and immune systems. Experiences during prenatal life also program the regulatory set points that will govern physiology in adulthood. During this malleable maturational phase, these biological processes should be viewed as flexible "learning systems" that guide the developmental trajectory toward health or derail it toward pathology. Our studies on infant primates have shown that the competence of their immune responses and the structure and activity of certain brain regions, as well as many aspects of behavior and emotional reactivity, are strongly affected by the pregnancy conditions of their mothers.