Rank‐related differences in cardiovascular function among wild baboons: Role of sensitivity to glucocorticoids
Rank‐related differences in cardiovascular function among wild baboons: Role of sensitivity to glucocorticoids
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DOI：
10.1002/ajp.1350320404
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发表时间：
1994
影响因子：
2.4
通讯作者：
R. Sapolsky;L. Share
中科院分区：
文献类型：
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作者：
R. Sapolsky;L. Share
在生活在东非的一群野生狒狒中，我们观察到个体之间的内分泌差异是优势度等级的函数。在这些差异中，我们之前观察到的间接证据表明，占优势的男性更多。它们对交感性儿茶酚胺的反应比从属雄性更强。本报告明确测试了这一点。已知等级的雄性狒狒被麻醉，交感和副交感神经活动被药物抑制。在实验一中，男性被肾上腺素刺激；在广泛的剂量范围内，优势男性的收缩压上升最大、最快，峰值收缩压最高，从肾上腺素挑战中恢复最快。在心率对肾上腺素的反应中，也出现了类似的等级相关差异。实验二表明，这种现象可能反映了心脏和血管系统中与等级相关的差异。作为证据，当男性被α受体激动剂苯肾上腺素(主要收缩全身静脉和小动脉)激发时，在收缩血压反应方面出现了相同的等级差异，而在刺激β受体激动剂异丙肾上腺素(它选择性地作用于心脏)后，心率反应出现了相同的等级差异。
In a population of wild baboons living in East Africa, we have observed endocrine differences among individuals as a function of dominance rank. Among these differences, we previously observed indirect evidence for dominant males being more. responsive to sympathetic catecholamines than were subordinate males. The present report tests this explicitly. Male baboons of known rank were anesthetized, and sympathetic and parasympathetic activity was pharmacologically inhibited. In experiment I, males were challenged with epinephrine; over a wide dose range, dominant males had the largest and fastest rises in systolic pressure, the greatest peak systolic pressure, and the most rapid recovery from the epinephrine challenge. Similar rank‐related differences in heart rate response to epinephrine also occurred. Experiment II showed that this phenomenon probably reflects rank‐related differences at both the heart and vasculature. As evidence, the same rank differences in systolic blood pressure responsiveness occurred when males were challenged with the alpha receptor agonist phenylephrine (which predominantly constricts systemic veins and arterioles), while the same rank differences in heart rate responses occurred following stimulation with the beta receptor agonist isoproterenol (which selectively works at the heart).