Inhibition of rat testicular heme synthesis and depression of microsomal cytochrome P-450 by estradiol benzoate.
Inhibition of rat testicular heme synthesis and depression of microsomal cytochrome P-450 by estradiol benzoate.
复制标题
苯甲酸雌二醇抑制大鼠睾丸血红素合成并抑制微粒体细胞色素 P-450。
DOI：
10.1016/0006-2952(82)90593-7
复制
发表时间：
1982
影响因子：
5.8
通讯作者：
Piper,WN
中科院分区：
文献类型：
--
作者：
Tofilon,PJ;Piper,WN
Twenty-four hours after a single dose (50 μg, s.c.) of estradiol benzoate (EB), rat testicular microsomal heme and cytochrome P-450 were decreased to 72 and 76% of control levels respectively. Treatment of rats with human chorionic gonadotropin (hCG) resulted in elevated levels of microsomal heme and cytochrome P-450 and increased activity of δ-aminolevulinic acid (ALA) synthase (EC 2.3.1.37). However, the hCG-mediated elevations of testicular microsomal heme and cytochrome P-450 content failed to occur in animals treated with EB. To investigate the possibility that the observed effect of EB was mediated through the pituitary, studies were conducted with hypophysectomized animals. The increased microsomal heme and cytochrome P-450 content mediated by hCG in hypophysectomized animals was again prevented by administration of EB. The elevated activity of testicular mitochondrial ALA synthase produced by hCG in both intact and hypophysectomized animals was not affected by EB. Incorporation of [13C]ALA into microsomal heme was depressed 60% 12 hr following a single dose of EB (50 μg, s.c.). These data suggest that EB depresses testicular microsomal heme and cytochrome P-450 content by inhibiting the synthesis of heme at an enzymatic reaction other than ALA synthase.
登录
查看更多内容
化学卟啉症中 δ-氨基乙酰丙酸合成酶合成的体外诱导：对某些药物、性激素和外来化学物质的反应。
影响因子：
4.8
作者：
S. Granick;Rita Lau
通讯作者：
Rita Lau
类固醇羟基化过程中肾上腺皮质线粒体的呼吸活动
DOI：
--
发表时间：
1967
期刊：
影响因子：
--
作者：
W. Cammer;R. Estabrook
通讯作者：
R. Estabrook
影响因子：
4.8
作者：
KALLA, NR;NISULA, BC;LORIAUX, DL
通讯作者：
LORIAUX, DL
一种快速简便获得放射化学纯肝血红素的方法
DOI：
--
发表时间：
1978
期刊：
影响因子：
--
作者：
H. Bonkowsky;W. Bement;R. Erny
通讯作者：
R. Erny
停止短期和长期雌二醇治疗后成年雄性大鼠睾丸和垂体功能的恢复。
影响因子：
3.6
作者：
R. Tcholakian;M. Chowdhury;A. K. Chowdhury
通讯作者：
A. K. Chowdhury