Correlated firing in rabbit retinal ganglion cells
Correlated firing in rabbit retinal ganglion cells
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DOI：
10.1152/jn.1999.81.2.908
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发表时间：
1999-02-01
影响因子：
2.5
通讯作者：
DeVries, SH
中科院分区：
文献类型：
--
作者：
DeVries, SH
神经节细胞的感受器被定义为视网膜表面上的区域，其中光刺激将产生反应。虽然相邻的神经节细胞可能会在它们的感受野重叠的区域对相同的刺激做出反应，但通常认为每个细胞都可以独立决定是否放电。最近的记录从猫和蝾螈视网膜使用多个电极已经挑战了这种观点的独立发射显示，相邻的神经节细胞有一个增加的倾向，在+/-5毫秒内一起发射。然而，仍然存在不确定性，哪些类型的神经节细胞一起发射，产生协调尖峰的机制，以及协调发射的整体功能。为了解决这些问题，使用多电极阵列同时记录多达80个兔视网膜神经节细胞的反应。在先前鉴定的11类兔神经节细胞中，在5类中观察到协调放电。尖峰串相关函数图表明，协同疲劳通过两种机制发生。在第一种机制中，一个中间神经元的尖峰分叉，在两个神经节细胞中同时产生尖峰。这种机制占主导地位的五个类，包括ON轻快瞬态细胞。在第二种机制中，神经节细胞似乎相互激活。这是在OFF轻快瞬态细胞中相关放电的主要模式。通过比较ON和OFF轻快瞬态细胞的接受保持曲线，确定了OFF轻快瞬态细胞感受野的外围延伸，这可能是由侧向锋电位扩散产生的。因此，一个单独的OFF轻快瞬态细胞既可以对指向其感受野中心的光刺激做出反应，也可以对通过其感受野中心激活相邻OFF轻快瞬态细胞的刺激做出反应。
A ganglion cell's receptive held is defined as that region on the retinal surface in which a light stimulus will produce a response. While neighboring ganglion cells may respond to the same stimulus in a region where their receptive fields overlap; it generally has been assumed that each cell makes an independent decision about whether to fire. Recent recordings from cat and salamander retina using multiple electrodes have challenged this view of independent firing by showing that neighboring ganglion cells have an increased tendency to fire together within +/-5 ms. However, there is still uncertainty about which types of ganglion cells fire together, the mechanisms that produce coordinated spikes, and the overall function of coordinated firing. To address these issues, the responses of up to 80 rabbit retinal ganglion cells were recorded simultaneously using a multielectrode array. Of the 11 classes of rabbit ganglion cells previously identified, coordinated firing was observed in five. Plots of the spike train cross-correlation function suggested that coordinated tiring occurred through two mechanisms. In the first mechanism, a spike in an interneuron diverged to produce simultaneous spikes in two ganglion cells. This mechanism predominated in four of the five classes including the ON brisk transient cells. In the second mechanism, ganglion cells appeared to activate each other reciprocally. This was the predominant pattern of correlated firing in OFF brisk transient cells. By comparing the receptive held profiles of ON and OFF brisk transient cells, a peripheral extension of the OFF brisk transient cell receptive field was identified that might be produced by lateral spike spread. Thus an individual OFF brisk transient cell can respond both to a Light stimulus directed at the center of its receptive field and to stimuli that activate neighboring OFF brisk transient cells through their receptive field centers.