Cell membranes, methods and reviews
Cell membranes, methods and reviews
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细胞膜、方法和评论
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
L. Glaser
中科院分区：
文献类型：
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作者：
E. Elson;W. Frazier;L. Glaser
这卷汇编在两个主要相关领域的主题评论。其中之一涉及细胞与基质和其他细胞的相互作用，这是由细胞外基质和可溶性分子介导的。正如本卷所述，这些相互作用负责控制从胚胎发生和神经发育到血液凝固的细胞功能。此外，细胞外基质的重要性质可以通过肿瘤细胞和成纤维细胞的相互作用来调节。另一个主要的研究领域是细胞对细胞外信号的反应。最近的工作已经开始揭示如何一个显着的多样性的细胞功能，包括神经元，增殖，膜-细胞骨架，和许多其他种类的反应，引起通过调解的一个相对较小的和相互依赖的第二信使系统。这些包括细胞质离子平衡的变化和各种蛋白激酶的激活。这两个主题都包括在本卷中。这两个领域通过细胞对外部环境的反应的共同主题联系在一起，该外部环境通过细胞与信息分子的相互作用来感知，这些信息分子是可溶性试剂，以及那些是不溶性基质的组分。直到最近，我们才开始认识到细胞周围的基质与细胞对激素和生长因子的反应之间的复杂相互作用。因此，我们试图选择这种类型的细胞外整合可能发挥作用的例子。"
This volume assembles reviews on topics in two major related areas. One of these concerns the interactions of cells with substrata and with other cells, which are mediated by the extracellular matrix and soluble molecules. As described in this volume, these interactions are responsible for controlling cell functions ranging from embryogenesis and neural development to blood clotting. More over, important properties of the extracellular matrix can be modulated by the interdependent actions of tumor cells and fibroblasts. The other major area of interest concerns the response of cells to extracellular signals. Recent work has begun to reveal how a remarkable diversity of cellular functions, including neuronal, proliferative, membrane--cytoskeletal, and many other kinds of re sponses, are elicited through the mediation of a relatively small and interdepen dent set of second messenger systems. These include both changes in cytoplasmic ionic balances and activation of various kinds of protein kinases. Both subjects are covered in this volume. The two areas are linked by the common theme of cellular response to an external environment that is sensed through cellular interactions with informational molecules, which are soluble agents, as well as those that are components of insoluble matrices. It is only recently that we have come to appreciate the complex interplay between the matrix surrounding a cell and the cell's response to hormones and growth factors. Thus, we have tried to select examples in which this type of extracellular integration may playa role."