Post-traumatic stress disorder: evidence-based research for the third millennium.
Post-traumatic stress disorder: evidence-based research for the third millennium.
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创伤后应激障碍：第三千年的循证研究。
DOI：
10.1093/ecam/neh127
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发表时间：
2005-12
影响因子：
--
通讯作者：
Chiappelli, F
中科院分区：
文献类型：
--
作者：
Iribarren, J;Prolo, P;Neagos, N;Chiappelli, F
创伤性事件造成的压力促成了一系列心理情绪和生理病理结果。创伤后应激障碍（PTSD）是一种精神疾病，由经历或目睹创伤或危及生命的事件引起。创伤后应激障碍有着深刻的心理生物学相关性，它会损害人的日常生活并危及生命。鉴于当前的事件（例如长期战斗，恐怖主义，暴露于某些环境毒素），预计未来十年PTSD诊断患者将急剧增加。创伤后应激障碍是一个严重的公共卫生问题，这迫使寻找新的范式和理论模型，以加深对病情的理解，并开发新的和改进的治疗干预模式。我们回顾了目前对PTSD的认识，并介绍了变稳态作为PTSD基础研究的新视角的作用。我们讨论了医学领域的循证研究，特别是在PTSD患者的补充医疗干预的背景下。我们提出的论点支持的概念，即未来的临床和转化研究在创伤后应激障碍在于治疗干预的研究证据的系统评价，以确保最有效和最有效的治疗患者的利益。
The stress that results from traumatic events precipitates a spectrum of psycho-emotional and physiopathological outcomes. Post-traumatic stress disorder (PTSD) is a psychiatric disorder that results from the experience or witnessing of traumatic or life-threatening events. PTSD has profound psychobiological correlates, which can impair the person's daily life and be life threatening. In light of current events (e.g. extended combat, terrorism, exposure to certain environmental toxins), a sharp rise in patients with PTSD diagnosis is expected in the next decade. PTSD is a serious public health concern, which compels the search for novel paradigms and theoretical models to deepen the understanding of the condition and to develop new and improved modes of treatment intervention. We review the current knowledge of PTSD and introduce the role of allostasis as a new perspective in fundamental PTSD research. We discuss the domain of evidence-based research in medicine, particularly in the context of complementary medical intervention for patients with PTSD. We present arguments in support of the notion that the future of clinical and translational research in PTSD lies in the systematic evaluation of the research evidence in treatment intervention in order to insure the most effective and efficacious treatment for the benefit of the patient.
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