Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus
Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus
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DOI：
10.1002/jcb.24402
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发表时间：
2013-03-01
影响因子：
4
通讯作者：
Chen, Shuqing
中科院分区：
文献类型：
--
作者：
Akash, Muhammad Sajid Hamid;Rehman, Kanwal;Chen, Shuqing
2型糖尿病（T2DM）的特征是进行性β细胞功能障碍和胰岛素抵抗。本文回顾了近年来的文献，特别关注炎症机制，引发2型糖尿病的发病机制。我们关注了T2DM进展的最新进展，包括可能诱导炎症、胰岛素抵抗、胰岛分泌减少和β细胞功能障碍的各种炎症机制。本文还综述了各种促炎介质在炎症机制中的作用，它们可能通过诱导胰岛细胞凋亡而进一步改变β细胞的正常结构。提示炎症在T2DM发病中的作用不容忽视。此外，对T2DM炎症反应的认识可能为更好地治疗糖尿病提供新的途径。J.细胞。114：525531，2013. (C)2012 Wiley Periodicals，Inc.
Type 2 diabetes mellitus (T2DM) is characterized by progressive beta-cell dysfunctioning and insulin resistance. This article reviews recent literature with special focus on inflammatory mechanisms that provoke the pathogenesis of T2DM. We have focused on the recent advances in progression of T2DM including various inflammatory mechanisms that might induce inflammation, insulin resistance, decrease insulin secretion from pancreatic islets and dysfunctioning of beta-cells. Here we have also summarized the role of various pro-inflammatory mediators involved in inflammatory mechanisms, which may further alter the normal structure of beta-cells by inducing pancreatic islet's apoptosis. In conclusion, it is suggested that the role of inflammation in pathogenesis of T2DM is crucial and cannot be neglected. Moreover, the insight of inflammatory responses in T2DM may provide a new gateway for the better treatment of diabetes mellitus. J. Cell. Biochem. 114: 525531, 2013. (C) 2012 Wiley Periodicals, Inc.