A prospective 2-year follow-up study of neurocognitive functioning in patients with first-episode schizophrenia
A prospective 2-year follow-up study of neurocognitive functioning in patients with first-episode schizophrenia
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DOI：
10.1007/s00406-002-0391-4
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发表时间：
2002-12-01
影响因子：
4.7
通讯作者：
Mohr, F
中科院分区：
文献类型：
--
作者：
Albus, M;Hubmann, W;Mohr, F
为了调查精神分裂症神经心理 (NP) 损伤的时间稳定性或进展性，50 名首发 (FE) 精神分裂症患者和 50 名健康对照者在研究开始时和两年间隔后接受了一系列测试。患者组和对照组在年龄、性别、教育程度和父母社会经济地位方面都是平衡的。构建了语义记忆（SEM）、视觉记忆（VIM）、言语学习（VBL）、视觉运动处理和注意力（VSM）以及抽象/灵活性（ABS）的总结评定量表。 FE 精神分裂症患者的 VBL 有所改善，SEM、VSM 和 ABS 功能稳定性有所改善，但 VIM 没有改善。虽然 VSM 和 VIM 的表现受到药物状态的影响，但 SEM 似乎与性状相关且稳定；然而，VBL 似乎与状态相关。我们的数据表明，没有证据表明在患病的最初几年中 NP 功能会逐渐恶化。
To investigate the temporal stability, or progressivity, of neuropsychological (NP) impairment in schizophrenia, 50 patients with first episode (FE) schizophrenia and 50 healthy controls were given a battery of tests at the outset of the study and after a two-year interval. Both patient and control groups were balanced with respect to age, gender, education and parental socioeconomic status. Summary rating scales for semantic memory (SEM), visual memory (VIM), verbal learning (VBL), visual-motor processing and attention (VSM) and abstraction/flexibility (ABS) were constructed. FE schizophrenics showed improvement in VBL, stability of function in SEM, VSM and ABS and absence of improvement in VIM. While performance in VSM and VIM is influenced by medication status, SEM seems to be trait-related and stable; VBL, however, seems to be state-related. Our data suggest that there is no proof for the assumption of progressive deterioration in NP functioning during the first few years of illness.