Perinatal Programming of Metabolic Diseases Role of Insulin in the Development of Hypothalamic Neurocircuits
Perinatal Programming of Metabolic Diseases Role of Insulin in the Development of Hypothalamic Neurocircuits
复制标题
DOI：
10.1016/j.ecl.2012.10.002
复制
发表时间：
2013-03-01
影响因子：
4.5
通讯作者：
Bruening, Jens C.
中科院分区：
文献类型：
--
作者：
Steculorum, Sophie M.;Vogt, Merly C.;Bruening, Jens C.
人们越来越多地接受，一个人的代谢未来可以编程早在发育阶段。例如，患有糖尿病的母亲的后代在以后的生活中患肥胖症和糖尿病的风险更大。动物研究表明，围产期高胰岛素血症和/或高血糖症会永久损害控制食欲和葡萄糖稳态的下丘脑网络的组织和长期功能。本文综述了围产期胰岛素和葡萄糖水平对下丘脑发育和不同啮齿动物模型中报告的代谢性疾病的长期规划的关键调节作用的主要研究结果。
It is increasingly accepted that the metabolic future of an individual can be programmed as early as at developmental stages. For instance, offspring of diabetic mothers have a greater risk of becoming obese and diabetic later in life. Animal studies have demonstrated that hyperinsulinemia and/or hyperglycemia during perinatal life permanently impair the organization and long-term function of hypothalamic networks that control appetite and glucose homeostasis. This review summarizes the main findings regarding the key regulatory roles of perinatal insulin and glucose levels on hypothalamic development and on long-term programming of metabolic diseases reported in different rodent models.