A Novel One-Pot, Three-Component Synthesis of 5-Imino-2,3,5,8-tetrahydropyrazolo[1,2-a]pyridazin-1-one Derivatives.
A Novel One-Pot, Three-Component Synthesis of 5-Imino-2,3,5,8-tetrahydropyrazolo[1,2-a]pyridazin-1-one Derivatives.
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5-亚氨基-2,3,5,8-四氢吡唑并[1,2-a]哒嗪-1-酮衍生物的新型一锅三组分合成。
DOI：
10.1002/chin.200939158
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Yong‐Min Liang
中科院分区：
文献类型：
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作者：
B. Qian;Mingjin Fan;Yong‐Xin Xie;Lu‐Yong Wu;Yun;Yong‐Min Liang
研究发现，在温和的条件下，由异氰酸酯加成得到的两性离子中间体能与1，3-偶极化合物反应，高产率地合成5-imino-2，3，5，8-tetrahydropyrazolo[1，2-a]pyridazin-1-one衍生物。对该过程的可能机理也进行了讨论。
It was found that the zwitterionic intermediate obtained from the addition of isocyanides to dimethyl acetylenedicarboxylate could react with 1,3-dipolar compounds under mild conditions to produce 5-imino-2,3,5,8-tetrahydropyrazolo[1,2-a]pyridazin-1-one derivatives in high yields. A plausible mechanism was also discussed for this process.