Phosphate: known and potential roles during development and regeneration of teeth and supporting structures.
Phosphate: known and potential roles during development and regeneration of teeth and supporting structures.
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DOI：
10.1002/bdrc.20136
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Somerman MJ
中科院分区：
文献类型：
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作者：
Foster BL;Tompkins KA;Rutherford RB;Zhang H;Chu EY;Fong H;Somerman MJ
无机磷酸盐（Pi）在细胞和组织中含量丰富，是核酸和磷脂的重要组成部分，是核苷三磷酸中高能键的来源，是激酶和磷酸酶的底物，是细胞内信号传导的调节剂。人体的大部分Pi存在于骨骼和牙齿的矿化基质中。全身Pi代谢通过骨-肾-肠轴受到一系列激素、磷酸素和其他因子的调节。骨和牙齿的矿化反过来受Pi和无机焦磷酸盐（PPi）的稳态影响，并通过细胞酶和转运体进一步调节Pi/PPi比率。通过分析Pi代谢改变的突变和敲除小鼠矿化组织发育变化的分子基础，我们了解了很多。本文综述了调节全身和局部Pi稳态的因素及其已知和推测的对口腔硬组织的影响。通过了解Pi代谢在口腔矿化组织的发育和维持中的作用，将有可能开发改进的再生方法。
Inorganic phosphate (Pi) is abundant in cells and tissues as an important component of nucleic acids and phospholipids, a source of high-energy bonds in nucleoside triphosphates, a substrate for kinases and phosphatases, and a regulator of intracellular signaling. The majority of the body’s Pi exists in the mineralized matrix of bones and teeth. Systemic Pi metabolism is regulated by a cast of hormones, phosphatonins, and other factors via the bone-kidney-intestine axis. Mineralization in bones and teeth is in turn affected by homeostasis of Pi and inorganic pyrophosphate (PPi), with further regulation of the Pi/PPi ratio by cellular enzymes and transporters. Much has been learned by analyzing the molecular basis for changes in mineralized tissue development in mutant and knock-out mice with altered Pi metabolism. This review focuses on factors regulating systemic and local Pi homeostasis and their known and putative effects on the hard tissues of the oral cavity. By understanding the role of Pi metabolism in the development and maintenance of the oral mineralized tissues, it will be possible to develop improved regenerative approaches.