Bacterial sepsis in patients with visceral leishmaniasis in Northwest Ethiopia.
Bacterial sepsis in patients with visceral leishmaniasis in Northwest Ethiopia.
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DOI：
10.1155/2014/361058
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发表时间：
2014-01-01
影响因子：
--
通讯作者：
Diro, Ermias
中科院分区：
文献类型：
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作者：
Endris, Mengistu;Takele, Yegnasew;Diro, Ermias
内脏利什曼病（VL）是影响世界最贫困人口的被忽视的疾病之一。脓毒症是VL患者死亡的预测因素之一。本研究的目的是评估的患病率和相关因素与细菌性败血症，病原体，和他们的抗菌药物敏感性模式之间的患者VL. METHODS：寄生虫学证实的VL患者怀疑败血症，从2012年2月至2012年5月入住贡德大学医院，埃塞俄比亚西北部，进行了一项横断面研究。血培养和其他临床样本收集和培养后的标准procedures.RESULTS：在83脓毒症疑似VL患者16（19.3%）培养证实细菌性脓毒症。最常见的分离微生物是金黄色葡萄球菌（68.8%; 11/16），包括两种耐甲氧西林分离株（MRSA）。局部细菌感染的患者更易发生细菌性脓毒症（P <0.001）。金黄色。并发局灶性细菌感染与细菌性脓毒症相关，表明局灶性感染可作为VL患者细菌性脓毒症的来源。在VL患者中，对局灶性感染进行仔细的临床评价并及时开始经验性抗生素治疗似乎是必要的。
BACKGROUND AND OBJECTIVES: Visceral leishmaniasis (VL) is one of the neglected diseases affecting the poorest segment of world populations. Sepsis is one of the predictors for death of patients with VL. This study aimed to assess the prevalence and factors associated with bacterial sepsis, causative agents, and their antimicrobial susceptibility patterns among patients with VL.METHODS: A cross-sectional study was conducted among parasitologically confirmed VL patients suspected of sepsis admitted to the University of Gondar Hospital, Northwest Ethiopia, from February 2012 to May 2012. Blood cultures and other clinical samples were collected and cultured following the standard procedures.RESULTS: Among 83 sepsis suspected VL patients 16 (19.3%) had culture confirmed bacterial sepsis. The most frequently isolated organism was Staphylococcus aureus (68.8%; 11/16), including two methicillin-resistant isolates (MRSA). Patients with focal bacterial infection were more likely to have bacterial sepsis (P < 0.001).CONCLUSIONS: The prevalence of culture confirmed bacterial sepsis was high, predominantly due to S. aureus. Concurrent focal bacterial infection was associated with bacterial sepsis, suggesting that focal infections could serve as sources for bacterial sepsis among VL patients. Careful clinical evaluation for focal infections and prompt initiation of empiric antibiotic treatment appears warranted in VL patients.