Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride
Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride
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DOI：
10.1016/j.etp.2009.05.008
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发表时间：
2010-03-01
影响因子：
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通讯作者：
Farombi, Ebenezer O.
中科院分区：
文献类型：
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作者：
Adesanoye, Omolola A.;Farombi, Ebenezer O.
扁桃斑鸠菊（MEVA）的甲醇提取物对四氯化碳毒性的可能调节作用，该植物在热带地区广泛食用，并在当地用于治疗发烧、黄疸、胃病和糖尿病。以1.2 g/kg体重的剂量每周3次连续3周经口给予CCl 4，可显著诱导明显的肝损伤，表现为血清酶ALT，AST，SALP和γ-GT。在以250和500 mg/kg的CCl 4处理之前，每周5次给予扁桃体的甲醇提取物，持续2周。kg剂量的提取物改善了这些酶活性的增加。同样地，苦杏仁的甲醇提取物使CCl 4诱导的胆固醇、甘油三酯和磷脂浓度的增加分别降低37.8%、30.6%和8.5%，并且降低胆固醇/磷脂比。然而，在750 mg/kg浸提液预处理时，这些参数增加。在500 mg/kg剂量的V. amygdalina的甲醇提取物下，CCl 4诱导的脂质过氧化同样减弱了57.2%。同样地，在500 mg/kg时，给药提取物显著增加了抗氧化酶：超氧化物歧化酶、谷胱甘肽S-转移酶和还原型谷胱甘肽的活性（P
The possible modulatory effect of methanolic extract of Vernonia amygdalina (MEVA), a plant widely consumed in the tropics and used locally in the treatment of fever, jaundice, stomach disorders and diabetes on the toxicity of CCl4. was investigated in male rats.Oral administration of CCl4 at a dose of 1.2 g/kg body weight 3 times a week for 3 weeks significantly induced marked hepatic injury as revealed by increased activity of the serum enzymes ALT, AST, SALP and gamma-GT. Methanolic extract of V. amygdalina administered 5 times a week for 2 weeks before CCl4 treatment at 250 and 500 mg/kg doses of the extract ameliorated the increase in the activities of these enzymes. Likewise the methanolic extract of V. amygdalina reduced file CCl4-induced increase in the concentrations of cholesterol, triglyceride and phospholipid by 37.8%, 30.6% and 8.5%, respectively, and a reduction In the cholesterol/phospholipids ratio. These parameters were however increased at 750 mg/kg extract pretreatment. CCl4-induced lipid peroxidation was likewise attenuated by 57.2% at 500 mg/kg dose of the methanolic extract of V. amygdalina. Similarly, administration of the extract increased the activities of the antioxidant enzymes: superoxide dismutase, glutathione S-transferase and reduced glutathione concentration significantly at 500 mg/kg (P