The Bcl-2 gene family and apoptosis.
The Bcl-2 gene family and apoptosis.
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DOI：
10.1007/bfb0102306
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
McDonnell, T J
中科院分区：
文献类型：
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作者：
Bruckheimer, E M;Cho, S H;McDonnell, T J
细胞凋亡或程序性细胞死亡是正常胚胎发育、维持成体组织稳态和抑制癌发生的重要过程。与滤泡性淋巴瘤相关的bcl-2蛋白在控制细胞凋亡和增强细胞存活以响应不同的凋亡刺激中起着突出的作用。进化上保守的bcl-2蛋白现在被认为是相关蛋白家族的成员，这些蛋白可以归类为死亡激动剂或死亡拮抗剂。在确定bcl-2及其家族成员在调节细胞凋亡中的作用方面的进展正在迅速推进。这篇综述详细介绍了目前bcl-2家族的成员和可能的功能机制，使bcl-2家族的蛋白质，无论是促进或抑制细胞死亡。
Apoptosis, or programmed cell death, is an essential process for normal embryonic development, maintaining homeostasis in adult tissues, and suppressing carcinogenesis. The bcl-2 protein, discovered in association with follicular lymphoma, plays a prominent role in controlling apoptosis and enhancing cell survival in response to diverse apoptotic stimuli. The evolutionarily conserved bcl-2 protein is now recognized as being a member of a family of related proteins which can be categorized as death agonists or death antagonists. Progress in defining the role of bcl-2 and its family members in regulating apoptosis is rapidly advancing. This review describes, in detail, current bcl-2 family members and the possible mechanisms of function which allow the bcl-2 family of proteins to either promote or suppress cell death.