Design and fabrication of enhanced polymer waveguide platforms for absorption-based optical chemical sensors
Design and fabrication of enhanced polymer waveguide platforms for absorption-based optical chemical sensors
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DOI：
10.1088/0957-0233/15/6/014
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发表时间：
2004-06-01
影响因子：
2.4
通讯作者：
MacCraith, BD
中科院分区：
文献类型：
--
作者：
Burke, CS;Polerecky, L;MacCraith, BD
本文报道了可大规模生产的聚合物波导芯片作为吸收型光化学传感器增强平台的发展。该芯片的设计是基于以前报道的理论研究有关的光学吸收为基础的传感器采用单反射配置的灵敏度的优化。在这里，理论分析扩展到一个多反射配置，以确定相互作用长度的灵敏度的依赖关系，并进行实验研究的结果。理论预测的最佳传感条件的存在证明经验通过检查涂有溶胶-凝胶衍生的传感层掺杂的比色pH指示剂的聚合物波导平台的pH响应。这项工作具有重大意义的小型化，一次性传感器平台的制造，表现出增强的灵敏度相比，利用更常用的光学配置。
The development of mass-producible polymer waveguide chips as enhanced platforms for absorption-based optical chemical sensors employing thin colorimetric films is reported here. The chip design is based on a previously reported theoretical study relating to the optimization of the sensitivity of optical absorption-based sensors employing a single reflection configuration. Here, the theoretical analysis is extended to a multiple reflection configuration in order to determine the dependence of sensitivity on interaction length, and the findings are investigated experimentally. The existence of the optimum sensing conditions predicted by theory is demonstrated empirically by examining the pH response of polymer waveguide platforms coated with a sol-gel derived sensing layer doped with a colorimetric pH indicator. This work has major implications for the fabrication of miniaturized, disposable sensor platforms that demonstrate enhanced sensitivity when compared with those utilizing more commonly employed optical configurations.