DIFFERENTIAL BEHAVIORAL INTERACTIONS BETWEEN THE DOPAMINE-D-1 ANTAGONIST SCH-23390 AND THE DOPAMINE-D-2 ANTAGONISTS METOCLOPRAMIDE AND SULPIRIDE IN NONHABITUATED MICE
DIFFERENTIAL BEHAVIORAL INTERACTIONS BETWEEN THE DOPAMINE-D-1 ANTAGONIST SCH-23390 AND THE DOPAMINE-D-2 ANTAGONISTS METOCLOPRAMIDE AND SULPIRIDE IN NONHABITUATED MICE
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DOI：
10.1016/0091-3057(90)90157-d
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发表时间：
1990-02-01
影响因子：
3.6
通讯作者：
STARR, MS
中科院分区：
文献类型：
--
作者：
CHANDLER, CJ;STARR, BS;STARR, MS
This study investigated the effects of the selective D-1 antagonist SCH 23390, when administered alone and in combination with a typical (metoclopramide) or atypical neuroleptic (sulpiride), on species-typical behaviours in nonhabituated mice. When tested singly, all three compounds caused a progressive dose-depdnent inhibition of locomotion, rearing and grooming, though their potencies varied widely. Mixtures of a threshold dose of 0.01 mg/kg SCH 23390 and metoclopramide (0.05-1.25 mg/kg) interacted synergistically to promote hypomotility and to decrease rearing, but did not affect grooming. By contrast, combinations of 0.01 mg/kg SCH 23390 and sulpiride (2-10 mg/kg) resulted in a marked potentiation of grooming, but only additive reductions in horizontal and vertical movements, consistent with sulpiride and metoclopramide occluding different populations of D-2 receptors. The results show that blockade of D-1 receptors and certain populations of D-2 receptors can interact positively to modify animal motor behaviour, and add a fresh perspective to the concept that these two types of dopamine receptor normally work interdependently to control movements of the body.
