TERATOGENIC EFFECTS OF BENZO[A]PYRENE IN DEVELOPING CHICK-EMBRYO
TERATOGENIC EFFECTS OF BENZO[A]PYRENE IN DEVELOPING CHICK-EMBRYO
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DOI：
10.1016/0378-4274(88)90041-0
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发表时间：
1988-03-01
影响因子：
3.5
通讯作者：
MEHROTRA, NK
中科院分区：
文献类型：
--
作者：
ANWER, J;MEHROTRA, NK
研究了苯并[a]芘（BP）对鸡胚发育的影响。在胚胎发育的不同阶段，通过卵黄囊途径暴露于不同剂量的BP。这导致生长迟缓，反映在较低的胚胎体重，减少冠臀长度和喙长。不正常的幸存者表现出明显扭曲的腿与缩短的骨头，腹部水肿，血肿，水泡和短脖子。这些发现表明，BP是一种致畸剂时，通过这一途径注射，和“水肿综合征”是一个可能的机制，造成致畸作用，在发育中的鸡胚时，处理BP。
The effect of benzo[a]pyrene (BP), an established carcinogen, on developing chick embryos was investigated. The embryos were exposed in different stages of development to various doses of BP via the yolk sac route. This resulted in retarded growth, as reflected by lower embryonic body weight, reduced crown-rump length and bill length. Abnormal survivors showed remarkably twisted legs with shortening of the bones, abdominal oedema, haematomas, blisters and a short neck. These findings suggest that BP is a teratogen when injected via this route, and the ''oedema syndrome'' is a possible mechanism causing teratogenic effects in developing chick embryos when treated with BP.