IDIOPATHIC PULMONARY FIBROSIS - PROGRESSION OF HONEYCOMBING AT THIN-SECTION CT
IDIOPATHIC PULMONARY FIBROSIS - PROGRESSION OF HONEYCOMBING AT THIN-SECTION CT
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DOI：
10.1148/radiology.189.3.8080483
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发表时间：
1993-12-01
期刊：
影响因子：
19.7
通讯作者：
UEDA, E
中科院分区：
文献类型：
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作者：
AKIRA, M;SAKATANI, M;UEDA, E
目的：评估计算机断层扫描（CT）上蜂窝状病变的进展，并确定疾病模式的一系列变化。材料和方法：对29例特发性肺纤维化患者的CT扫描结果进行回顾，这些患者至少间隔1-52个月进行了两次连续CT检查。12名患者未接受任何治疗，17名患者接受了皮质类固醇治疗。初始和随访CT扫描独立评估，然后直接相互比较。结果：29例患者中有26例出现蜂窝状进展，在CT上是可变的（中位数，每月0.4%[范围，0%-11%]），但未经治疗和治疗的患者之间无显著差异。CT扫描的磨玻璃衰减区域先于并预测了该位置蜂窝状病变的发展。皮质类固醇治疗减少了磨玻璃衰减区域，但CT扫描上的蜂窝是不可逆的。结论：低剂量糖皮质激素治疗不能充分抑制肺泡炎以防止肺泡结构的持续恶化。
PURPOSE: To evaluate the progression of honeycombing at computed tomography (CT) and to determine serial changes in the pattern of disease.MATERIALS AND METHODS: CT scans, obtained in 29 patients with idiopathic pulmonary fibrosis who had undergone at least two serial CT examinations 1-52 months apart, were reviewed. Twelve patients had received no treatment, and 17 patients had received corticosteroids. Initial and follow-up CT scans were evaluated independently and then directly compared with each other.RESULTS: Twenty-six of the 29 patients showed progression of honeycombing, which was variable at CT (median, 0.4% [range, 0%-11%] per month) but not significantly different between untreated and treated patients. Areas of ground-glass attenuation on CT scans preceded and were predictive of the development of honeycombing in that location. Corticosteroid treatment reduced areas of ground-glass attenuation,but honey-combing on CT scans was irreversible.CONCLUSION: Low-dose therapy with corticosteroids does not suppress alveolitis sufficiently to prevent continued deterioration of the alveolar structures.