Allopurinol for refractory aggression and self-inflicted behaviour
Allopurinol for refractory aggression and self-inflicted behaviour
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DOI：
10.1177/026988110001400112
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发表时间：
2000-03-01
影响因子：
4.1
通讯作者：
Souza, DO
中科院分区：
文献类型：
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作者：
Lara, DR;Belmonte-de-Abreu, P;Souza, DO
以腺苷能活动减少为特征的嘌呤能系统受损，已被认为与攻击行为的神经生物学有关。由于没有直接的腺苷激动剂可供人类使用，因此用别嘌醇抑制嘌呤降解被认为是一种可能的策略。我们报告两例成人难治性攻击性行为由于神经系统疾病(一主要是自己造成的行为)与治疗的戏剧性反应，别嘌醇，300毫克/天。这些初步结果加强了嘌呤能系统在攻击性神经生物学中的参与，证明了进一步测试别嘌醇作为一种治疗攻击性和自我造成的行为的新方法是合理的。
The impairment of the purinergic system, characterized by reduced adenosinergic activity, has been implicated in the neurobiology of aggressive behaviour. Since there are no direct adenosine agonists available for human use, inhibition of purine degradation by allopurinol was conceived as a possible strategy. We report two cases of adults with refractory aggressive behaviour due to a neurological condition (one mainly with self-inflicted behaviour) with dramatic response to therapy with allopurinol, 300 mg/day p.o. These preliminary results reinforce the involvement of the purinergic system in the neurobiology of aggression, warranting further testing of allopurinol as a new treatment for aggressive and self-inflicted behaviours.