Effects of medication on parotid salivary flow rates in an individual with dementia of the Alzheimer type.
Effects of medication on parotid salivary flow rates in an individual with dementia of the Alzheimer type.
复制标题
药物对阿尔茨海默型痴呆患者腮腺唾液流量的影响。
DOI：
10.1111/j.1754-4505.1993.tb01499.x
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Oppenheim,FG
中科院分区：
文献类型：
--
作者：
Fedele,DJ;Jones,JA;Volicer,L;Herz,LR;Oppenheim,FG
药物对阿尔茨海默型痴呆患者腮腺唾液流率的影响关于唾液功能与特异性药物治疗之间关系的可用数据很少。我们测量了与药物治疗相关的未刺激和刺激的腮腺唾液流率。我们的辅助研究设计是一项N = 1的双盲随机对照试验，患者接受安慰剂或积极治疗的一系列治疗组。本研究的目的是为诊断为阿尔茨海默型痴呆的顽固性患者找到“最佳单一药物”治疗方法。本研究表明，硫代噻吩对腮腺血流的影响不一致。奥西泮对腮腺功能无影响，盐酸苯海拉明作用不一致，但普遍为负作用。数据还显示，与平均“正常”值相比，患有阿尔茨海默型痴呆的个体具有较低的基线未刺激和刺激腮腺唾液流量；然而，他们的流量却高于“正常”志愿者中最低的10%。
Effects of medication on parotid salivary flow rates in an individual with dementia of the Alzheimer typeData available on the relationship between salivary function and specific drug therapy are sparse. We measured unstimulated and stimulated parotid salivary flow rates associated with the drug therapies. Our ancillary study design is an N = 1 double‐blind randomized controlled trial in which the patient undergoes a series of treatment blocks of either placebo or active treatment. The purpose of the parent N of 1 study was to find the “best single drug” treatment for a resistive patient diagnosed with dementia of the Alzheimer type.This study demonstrates that thiothixene was associated with inconsistent effects on parotid flow. Oxazepam had no effect on his parotid function, and diphenhydramine hydrochloride had inconsistent but generally negative effects. The data also show that this individual with dementia of the Alzheimer type had lower baseline unstimulated and stimulated parotid salivary flow rates when compared with mean “normal” values; however, flow rates were above the lowest 10th percentile of “normal” volunteers.