Fast Functional Brain Imaging Using Constrained Reconstruction Based on Regularization Using Arbitrary Projections
Fast Functional Brain Imaging Using Constrained Reconstruction Based on Regularization Using Arbitrary Projections
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DOI：
10.1002/mrm.22009
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发表时间：
2009-08-01
影响因子：
3.3
通讯作者：
Hennig, Juergen
中科院分区：
文献类型：
--
作者：
Grotz, Thimo;Zahneisen, Benjamin;Hennig, Juergen
这项工作描述了一种新的方法，高度欠采样投影成像使用约束重建Tikhonov-Phillips正则化和其应用程序的高时间分辨率功能磁共振成像（fMRI）在80毫秒的重复时间。高分辨率的参考图像作为在体内线圈灵敏度是在一个单独的收购使用其他相同的参数。使用标准棋盘激活范例的激活研究证明了将激活相关效应与“生理噪声”分离的可能性所提供的固有高灵敏度。".在这第一个证明的原则的约束重建的正则化的基础上，使用任意投影（COBRA）技术，实验中进行了一个单一的切片模式，它允许在相同的时间分辨率与快速单切片回波平面成像（EPI）的比较。COBRA方法可以扩展到三维（3D）编码，而不会在时间性能上有严重的损失。对全局信号变化的分析表明，与标准EPI相比，COBRA具有出色的再现性。通过分别对每个单独的呼吸和ECG周期进行生理校正来去除心电图（ECG）相关和呼吸相关信号波动的可能性，大大改进了激活分析。Magn Reson Med 62：394-405，2009. (C)2009 Wiley-Liss，Inc.
This work describes a novel method for highly undersampled projection imaging using constrained reconstruction by Tikhonov-Phillips regularization and its application for high temporal resolution functional MRI (fMRI) at a repetition time of 80 ms. The high-resolution reference image used as in vivo coil sensitivity is acquired in a separate acquisition using otherwise identical parameters. Activation studies using a standard checkerboard activation paradigm demonstrate the inherent high sensitivity afforded by the possibility to separate activation-related effects from "physiological noise.". In this first proof-of-principle of the constrained reconstruction based on regularization using arbitrary projections (COBRA) technique, experiments are performed in a single-slice mode, which allows for a comparison with fast single-slice echo-planar imaging (EPI) at equal temporal resolution. The COBRA method can be extended to three-dimensional (3D) encoding without severe penalty in temporal performance. Analysis of the global signal change demonstrates the excellent reproducibility of COBRA compared to standard EPI. Activation analysis is considerably improved by the possibility to remove electrocardiogram (ECG)related and breathing-related signal fluctuations by physiological correction of each individual breathing and ECG cycle, respectively. Magn Reson Med 62:394-405, 2009. (C) 2009 Wiley-Liss, Inc.