STRUCTURE AND FUNCTION OF THE STRATUM-CORNEUM PERMEABILITY BARRIER
STRUCTURE AND FUNCTION OF THE STRATUM-CORNEUM PERMEABILITY BARRIER
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DOI：
10.1002/ddr.430130203
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发表时间：
1988-01-01
影响因子：
3.8
通讯作者：
ELIAS, PM
中科院分区：
文献类型：
--
作者：
ELIAS, PM
表皮的主要功能是产生不透水的外层，即角质层。角质层可以被认为在形态学和功能上代表一个由以下两部分组成的双室系统：(1)无核角质层（砖块），主要由纤维蛋白网络组成；(2)细胞间基质（灰浆），主要由中性脂质组成。先前和目前关于角质层的研究主要集中在导致角质层角质细胞形成的蛋白质生物化学上，而本文关注的是角质层细胞间基质的形成、组成和功能。对于那些对通透性屏障功能、经皮转运、皮肤储藏库以及大多数遗传性角化疾病感兴趣的人来说，理解“灰浆”是至关重要的，因为正是这个领域在逻辑上调节了所有这些重要的现象。
The main function of the epidermis is to generate an impermeable outer layer, the stratum corneum. The stratum corneum can be considered morphologically and functionally to represent a two‐compartment system composed of: (1) anucleate corneocytes (the bricks), largely composed of fibrous protein networks; and (2) the intercellular matrix (the mortar), predominantly composed of neutral lipid. Whereas much prior and current work on the stratum corneum has focused on the protein biochemistry leading to the formation of the keratinized corneocyte (“keratinization”), this paper is concerned with the formation, composition, and function of the intercellular matrix of the stratum corneum. For those interested in permeability barrier function, percutaneous transport, and the cutaneous reservoir, as well as most inherited disorders of cornification, it is critical to understand the “mortar,” for it is this domain that logically regulates all of these important phenomena.