Treatment with telmisartan/rosuvastatin combination has a beneficial synergistic effect on ameliorating Th17/Treg functional imbalance in hypertensive patients with carotid atherosclerosis
Treatment with telmisartan/rosuvastatin combination has a beneficial synergistic effect on ameliorating Th17/Treg functional imbalance in hypertensive patients with carotid atherosclerosis
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DOI：
10.1016/j.atherosclerosis.2013.12.004
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发表时间：
2014-03-01
期刊：
影响因子：
5.3
通讯作者：
Qi, Zaiwen
中科院分区：
文献类型：
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作者：
Liu, Zhendong;Zhao, Yingxin;Qi, Zaiwen
目的：目的：探讨血管紧张素II受体阻滞剂（ARBs）与他汀类药物对高血压合并颈动脉粥样硬化患者Th 17/Treg功能失衡的协同作用。将159例高血压合并颈动脉粥样硬化患者随机分为对照组、替米沙坦组、瑞舒伐他汀组和在氢氯噻嗪治疗基础上联合用药组（替米沙坦+瑞舒伐他汀）。观察颈动脉超声、Th 17/Treg功能轴、白细胞介素（IL）-1 β、IL-2、干扰素（IFN）-γ、超敏C反应蛋白（hsCRP）、单核细胞趋化蛋白（MCP）-1等指标。替米沙坦与瑞舒伐他汀联合用药在降低颈动脉内膜中层厚度（IMT）、Th 17细胞频率、IL-17、IL-6、IL-23、肿瘤坏死因子（TNF）-α、视黄酸受体相关孤儿受体（ROR）γ t mRNA表达、Th 17/Treg比值、IL-1 β、IL-2、IFN-γ、hsCRP和MCP-1方面具有显著协同效应，Treg细胞频率、IL-10、转化生长因子（TGF）-β 1和叉头/翼状螺旋转录因子（Foxp 3）mRNA表达均增加（P均< 0.05）。IMT的变化率与Th 17细胞频率、IL-17、IL-6、IL-23、TNF-α、ROR γ t mRNA表达、Th 17/Treg比值、IL-1 β、IL-2、IFN-γ、hsCRP和MCP-1的下降率呈正相关，与Treg频率、IL-10、TGF-β 1和Foxp 3 mRNA表达的升高率呈负相关，结论：替米沙坦联合瑞舒伐他汀对改善高血压合并颈动脉粥样硬化患者Th 17/Treg功能失衡具有协同作用。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Objectives: To explore synergistic effect between angiotensin II receptor blockers (ARBs) and statins on Th17/Treg functional imbalance in hypertensive patients with carotid atherosclerosis.Methods: This study was a 2 x 2 factorial randomized, prospective, double-blind, placebo-controlled trial. One hundred and fifty nine hypertensive patients with carotid atherosclerosis were randomized to the administration of control group, telmisartan group, rosuvastatin group, and combination group (telmisartan plus rosuvastatin) base on hydrochlorothiazide treatment. Carotid ultrasonography, parameters of Th17/Treg functional axis, interleukin (IL)-1 beta, IL-2, interferon (IFN)-gamma, hypersensitive C-reactive protein (hsCRP), monocyte chemotactic protein (MCP)-1 were evaluated.Results: Blood pressure level markedly reduced in four groups. There was significantly synergistic effect of combination of telmisartan with rosuvastatin on reducing carotid imtima-media thickness (IMT), Th17 cells frequency, IL-17, IL-6, IL-23, tumor necrosis factor (TNF)-alpha, expression of retinoic acid receptor-related orphan receptor (ROR)gamma t mRNA, Th17/Treg ratio, IL-1 beta, IL-2, IFN-gamma, hsCRP, and MCP-1, and increasing Treg cells frequency, IL-10, transforming growth factor(TGF)-beta 1, and expression of forkhead/winged helix transcription factor (Foxp3) mRNA (all P < 0.05). Change rate of IMT statistical positively related to descent rates of Th17 cells frequency, IL-17, IL-6, IL-23, TNF-alpha, expression of ROR gamma t mRNA, Th17/Treg ratio, IL-1 beta, IL-2, IFN-gamma, hsCRP, and MCP-1, and negatively related to increased rates of Treg frequency, IL-10, TGF-beta 1, and expression of Foxp3 mRNA, respectively (all P < 0.05).Conclusion: There is a synergistic effect of combination of telmisartan with rosuvastatin on ameliorating Th17/Treg functional imbalance in hypertensive patients with carotid atherosclerosis. (C) 2014 Elsevier Ireland Ltd. All rights reserved.