OVARIAN INFLUENCES ON MEAL PATTERNS OF FEMALE RATS
OVARIAN INFLUENCES ON MEAL PATTERNS OF FEMALE RATS
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DOI：
10.1016/0031-9384(76)90064-0
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发表时间：
1976-01-01
影响因子：
2.9
通讯作者：
WADE, GN
中科院分区：
文献类型：
--
作者：
BLAUSTEIN, JD;WADE, GN
研究了雌性大鼠的发情周期、卵巢切除和雌二醇替代对液体喂养的自由饲养模式的影响。发情前期食物摄入量的减少是通过减少食量和不完全补偿的增加进餐频率来实现的。卵巢切除引起的贪食表现为进食量的增加和进食次数的减少。当食物摄取量恢复到术前水平时，饭量仍然增加，而频率进一步减少。苯甲酸雌二醇（2 .mu）G /d)使长期切除卵巢的大鼠食量永久减少。随后又恢复到对照组的食物摄入水平，主要是由于进餐频率的增加。由雌二醇停药和替代引起的食物摄入量的短暂变化显然是通过膳食量的永久性变化以及每天膳食数量的代偿性变化来实现的。发情期餐量的减少可能是由于雌二醇对终止短期食物摄入机制的直接影响，而不是继发于每日总食物摄入水平的变化。
The effects of estrus cycles, ovariectomy and estradiol-replacement on free-feeding meal patterns of female rats maintained on a liquid diet were examined. The proestrus decrease in food intake was accomplished by a decrease in meal size and a less than fully compensatory increase in meal frequency. The hyperphagia induced by ovariectomy was reflected in an increase in meal size and a decrease in meal frequency. When food intake returned to preoperative levels, meal size remained elevated while frequency decrease further. Estradiol benzoate (2 .mu.g/day) permanently decreased meal size in long-term ovariectomized rats. The subsequent return to food intake levels of controls was due primarily to an increase in meal frequency. The transient changes in food intake caused by estradiol withdrawal and replacement are apparently accomplished by permanent changes in meal size followed by compensatory changes in the number of meals consumed per day. The decrease in meal size at proestrus may be due to a direct effect of estradiol on the mechanisms that terminate short-term food intake and may not be secondary to changes in the level of total daily food intake.